GAPDH - glyceraldehyde-3-phosphate dehydrogenase Gene
Also Known as G3PD; GAPD; HEL-S-162eP
Species: Homo sapiens
About GAPDH
This gene has 11 transcripts (splice variants), 422 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 1203.9), heart (RPKM 1083.8) and 24 other tissues.
Summary
This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible Oxidative Phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a Transferrin Receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
GAPDH Products (5)
| mRNA | Protein | Name |
|---|---|---|
| NM_001256799.3 | NP_001243728.1 | glyceraldehyde-3-phosphate dehydrogenase isoform 2 |
| NM_001289745.3 | NP_001276674.1 | glyceraldehyde-3-phosphate dehydrogenase isoform 1 |
| NM_001289746.2 | NP_001276675.1 | glyceraldehyde-3-phosphate dehydrogenase isoform 1 |
| NM_001357943.2 | NP_001344872.1 | glyceraldehyde-3-phosphate dehydrogenase isoform 4 |
| NM_002046.7 | NP_002037.2 | glyceraldehyde-3-phosphate dehydrogenase isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables aspartic-type endopeptidase inhibitor activity |
IDA
IDA: Inferred from direct assay
|
22832495 | GOA |
| enables disordered domain specific binding |
IPI
IPI: Inferred from physical interaction
|
11785981 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
20392205 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
11724794 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of GAIT complex |
IDA
IDA: Inferred from direct assay
|
15479637 | GOA |
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
11785981 | GOA |
| located in cytosol |
IDA
IDA: Inferred from direct assay
|
24101517 | GOA |
| located in lipid droplet |
IDA
IDA: Inferred from direct assay
|
14741744 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
28404743 | GOA |
| part of ribonucleoprotein complex |
IDA
IDA: Inferred from direct assay
|
15479637 | GOA |
GAPDH Protein Structure
Gp_dh_N: Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain (4 - 152)
Gp_dh_C: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain (157 - 314)
- 0
- 100
- 200
- 300
- 335 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
glyceraldehyde-3-phosphate dehydrogenase |
|
GAPDH Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
GAPDH | P04406 | ADAMTSL4 | Homo sapiens | Q6UY14-3 | 32814053 | |
|
Intra
|
GAPDH | P04406 | ADAMTSL4 | Homo sapiens | Q6UY14-3 | 32814053 | |
|
Intra
|
GAPDH | P04406 | ADAMTSL4 | Homo sapiens | Q6UY14-3 | 32814053 | |
|
Intra
|
GAPDH | P04406 | PREP | Homo sapiens | P48147 | 23348613 | |
|
Intra
|
GAPDH | P04406 | PREP | Homo sapiens | P48147 | 23348613 | |
|
Intra
|
GAPDH | P04406 | PREP | Homo sapiens | P48147 | 23348613 | |
|
Intra
|
GAPDH | P04406 | GAPDHS | Homo sapiens | O14556 | 33961781 | |
|
Intra
|
GAPDH | P04406 | GAPDHS | Homo sapiens | O14556 | 28514442 | |
|
Intra
|
GAPDH | P04406 | PUF60 | Homo sapiens | Q9UHX1-2 | 32814053 | |
|
Intra
|
GAPDH | P04406 | PUF60 | Homo sapiens | Q9UHX1-2 | 32814053 | |
|
Intra
|
GAPDH | P04406 | PUF60 | Homo sapiens | Q9UHX1-2 | 32814053 | |
|
Intra
|
GAPDH | P04406 | CAMK2A | Homo sapiens | Q9UQM7 | 32814053 | |
|
Intra
|
GAPDH | P04406 | CAMK2A | Homo sapiens | Q9UQM7 | 32814053 | |
|
Intra
|
GAPDH | P04406 | CAMK2A | Homo sapiens | Q9UQM7 | 32814053 | |
|
Intra
|
GAPDH | P04406 | KAT5 | Homo sapiens | Q92993-2 | 32814053 | |
|
Intra
|
GAPDH | P04406 | KAT5 | Homo sapiens | Q92993-2 | 32814053 | |
|
Intra
|
GAPDH | P04406 | KAT5 | Homo sapiens | Q92993-2 | 32814053 | |
|
Intra
|
GAPDH | P04406 | EGFR | Homo sapiens | P00533 | 24658140 | |
|
Intra
|
GAPDH | P04406 | TXN | Homo sapiens | P10599 | 32814053 | |
|
Intra
|
GAPDH | P04406 | S100A8 | Homo sapiens | P05109 | 25417112 | |
|
Intra
|
GAPDH | P04406 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
GAPDH | P04406 | TXN | Homo sapiens | P10599 | 32814053 | |
|
Intra
|
GAPDH | P04406 | S100A8 | Homo sapiens | P05109 | 25417112 | |
|
Intra
|
GAPDH | P04406 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
GAPDH | P04406 | S100A8 | Homo sapiens | P05109 | 25417112 | |
|
Intra
|
GAPDH | P04406 | TXN | Homo sapiens | P10599 | 32814053 | |
|
Intra
|
GAPDH | P04406 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
GAPDH | P04406 | PCNA | Homo sapiens | P12004 | 20849852 | |
|
Intra
|
GAPDH | P04406 | AK3 | Homo sapiens | Q9UIJ7 | 32814053 | |
|
Intra
|
GAPDH | P04406 | AK3 | Homo sapiens | Q9UIJ7 | 32814053 | |
|
Intra
|
GAPDH | P04406 | AK3 | Homo sapiens | Q9UIJ7 | 32814053 | |
|
Intra
|
GAPDH | P04406 | CRMP1 | Homo sapiens | Q14194 | 32814053 | |
|
Intra
|
GAPDH | P04406 | CRMP1 | Homo sapiens | Q14194 | 32814053 | |
|
Intra
|
GAPDH | P04406 | CRMP1 | Homo sapiens | Q14194 | 32814053 | |
|
Intra
|
GAPDH | P04406 | PRKACA | Homo sapiens | P17612 | 32814053 | |
|
Intra
|
GAPDH | P04406 | PRKACA | Homo sapiens | P17612 | 32814053 | |
|
Intra
|
GAPDH | P04406 | PRKACA | Homo sapiens | P17612 | 32814053 | |
|
Intra
|
GAPDH | P04406 | CTNNB1 | Homo sapiens | P35222 | 32814053 | |
|
Intra
|
GAPDH | P04406 | CTNNB1 | Homo sapiens | P35222 | 32814053 | |
|
Intra
|
GAPDH | P04406 | CTNNB1 | Homo sapiens | P35222 | 32814053 | |
|
Intra
|
GAPDH | P04406 | FYN | Homo sapiens | P06241 | 32814053 | |
|
Intra
|
GAPDH | P04406 | FYN | Homo sapiens | P06241 | 32814053 | |
|
Intra
|
GAPDH | P04406 | FYN | Homo sapiens | P06241 | 32814053 | |
|
Intra
|
GAPDH | P04406 | RPA2 | Homo sapiens | P15927 | 16169070 | |
|
Intra
|
GAPDH | P04406 | NOS2 | Homo sapiens | P35228 | 25417112 | |
|
Intra
|
GAPDH | P04406 | PGK1 | Homo sapiens | P00558 | 20392205 | |
|
Intra
|
GAPDH | P04406 | TINF2 | Homo sapiens | Q9BSI4 | 21044950 | |
|
Intra
|
GAPDH | P04406 | SLC41A3 | Homo sapiens | Q96GZ6 | 32814053 | |
|
Intra
|
GAPDH | P04406 | SLC41A3 | Homo sapiens | Q96GZ6 | 32814053 | |
|
Intra
|
GAPDH | P04406 | SLC41A3 | Homo sapiens | Q96GZ6 | 32814053 | |
|
Intra
|
GAPDH | P04406 | APP | Homo sapiens | P05067 | 32814053 | |
|
Intra
|
GAPDH | P04406 | APP | Homo sapiens | P05067 | 32814053 | |
|
Intra
|
GAPDH | P04406 | APP | Homo sapiens | P05067 | 32814053 |
Recombinant GAPDH Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P72201 | GAPDH Protein, Human (His-SUMO) | P04406-1 (G2-E335) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P78776 | GAPDH Protein, Human (HEK293, His) | AAH01601 (G2-E335) | ≥ 95%, as determined by reducing SDS-PAGE. |
GAPDH Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80954 | GAPDH Antibody (YA848) | WB | Human, Monkey, Rat, Mouse, Saccharomyces cerevisiae, Pichia pastoris, Hamster |
| HY-P80954A | GAPDH Antibody (HRP) (YA874) | WB, ELISA | Human, Mouse, Rat |
| HY-P83944 | GAPDH Antibody (YA3641) | WB, IHC-P, ICC/IF, FC, ELISA | Human, Mouse, Rat, Rabbit, Monkey, Pig |
| HY-P83944A | GAPDH Antibody (YA3641)(PBS only) | WB, IHC-P, ICC/IF, FC, ELISA | Human, Mouse, Rat, Rabbit, Monkey, Pig |
| HY-P86316 | GAPDH Antibody (YA6008) | WB, IHC-P, ICC/IF | Human, Mouse, Rat, Rabbit, Zebrafish |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Microcephaly 21, Primary, Autosomal Recessive |
|
|
| Aging |
|
|
| Schistosomiasis |
|
|
| Sleeping Sickness |
|
|
| Dentatorubral-Pallidoluysian Atrophy |
|
|
| Osteochondritis Dissecans |
|
|
| Polyomavirus-Associated Nephropathy |
|
|
| Alcoholic Liver Cirrhosis |
|
|
| Myoglobinuria |
|
|
| Malaria |
|
|
| Endocarditis |
|
|
| Bone Cancer |
|
|
| Tongue Carcinoma |
|
|
| Glomerulonephritis |
|
|
| Muscular Atrophy |
|
|
| Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type |
|
|
| Bladder Cancer |
|
|
| Ovarian Disease |
|
|
| Vascular Disease |
|
|
| Colorectal Cancer |
|
|
| Urethra Transitional Cell Carcinoma |
|
|
| Intraocular Pressure Quantitative Trait Locus |
|
|
| Prostate Cancer |
|
|
| Gastric Cancer |
|
|
| Infertility |
|
|
| Parkinson Disease, Late-Onset |
|
|
| Macular Degeneration, Age-Related, 1 |
|
|
| Sudden Infant Death Syndrome |
|
|
| Diabetes Mellitus |
|
|
| Ovarian Cancer |
|
|
| Gallbladder Cancer |
|
|
| Phenylketonuria |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Leukemia, Acute Monocytic |
|
|
| Neuroblastoma |
|
|
| Ureteral Disease |
|
|
| Uruguay Faciocardiomusculoskeletal Syndrome |
|
|
| Syndromic X-Linked Intellectual Disability |
|
|
| Brain Glioblastoma Multiforme |
|
|
| Esophageal Cancer |
|
|
| Autonomic Nervous System Neoplasm |
|
|
| Bone Deterioration Disease |
|
|
| Peripheral Nervous System Neoplasm |
|
|
| Diaphragmatic Hernia, Congenital |
|
|
| Cervix Carcinoma |
|
|
| Iga Glomerulonephritis |
|
|
| Colorectal Adenocarcinoma |
|
|
| Urinary Tract Obstruction |
|
|
| Ovary Adenocarcinoma |
|
|
| Huntington Disease |
|
|
| Amino Acid Metabolic Disorder |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
| Breast Adenocarcinoma |
|
|
| Retinitis Pigmentosa |
|
|
| Suppression Of Tumorigenicity 12 |
|
|
| Endocervical Carcinoma |
|
|
| Pain Agnosia |
|
|
| Hypertension, Essential |
|
|
| Schizophrenia |
|
|
| Hypopharynx Cancer |
|
|
| Ovarian Cystadenocarcinoma |
|
|
| Toxic Encephalopathy |
|
|
| Retinitis Pigmentosa 11 |
|
|
| Brain Glioma |
|
|
| Mycobacterium Tuberculosis 1 |
|
|
| Leukemia, Chronic Myeloid |
|
|
| Rectum Adenocarcinoma |
|
|
| Agnosia |
|
|
| Amelogenesis Imperfecta, Type Ig |
|
|
| Bone Sarcoma |
|
|
| Estrogen-Receptor Negative Breast Cancer |
|
|
| Endocervical Adenocarcinoma |
|
|
| Germ Cell Cancer |
|
|
| Lung Cancer |
|
|
| Lung Cancer Susceptibility 3 |
|
|
| Myocardial Infarction |
|
|
| Bone Inflammation Disease |
|
|
| Breast Cancer |
|
|
| Malignant Ovarian Surface Epithelial-Stromal Neoplasm |
|
|
| Immune Deficiency Disease |
|
|
| Tongue Disease |
|
|
| Adult Syndrome |
|
|
| Bone Structure Disease |
|
|
| Heart Disease |
|
|
| Corneal Disease |
|
|
| Specific Developmental Disorder |
|
|
| Uterine Corpus Cancer |
|
|
| Syndromic Intellectual Disability |
|
|
| Cataract 9, Multiple Types |
|
|
| Peripheral Nervous System Disease |
|
|
| Sensory System Disease |
|
|
| Deficiency Anemia |
|
|
| Meningioma, Familial |
|
|
| Chromophobe Renal Cell Carcinoma |
|
|
| Gallbladder Disease |
|
|
| Tongue Squamous Cell Carcinoma |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Colonic Benign Neoplasm |
|
|
| Eye Degenerative Disease |
|
|
| Bone Osteosarcoma |
|
|
| Physical Disorder |
|
|
| Premature Menopause |
|
|
| Osebold-Remondini Syndrome |
|
|
| Head And Neck Cancer |
|
|
| Dilated Cardiomyopathy |
|
|
| Amelogenesis Imperfecta |
|
|
| Distal Arthrogryposis |
|
|
| Eye Disease |
|
|
| Interstitial Lung Disease 2 |
|
|
| Wilms Tumor 1 |
|
|
| Connective Tissue Disease |
|
|
| Nervous System Disease |
|
|
| Skin Disease |
|
|
| Leukemia, Acute Myeloid |
|
|
| Osteochondrodysplasia |
|
|
| Melanoma, Uveal |
|
|
| Neuromuscular Disease |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
| Hypertrophic Cardiomyopathy |
|
|
| Hirschsprung Disease 1 |
|
|
| Acute Promyelocytic Leukemia |
|
|
| Congenital Nervous System Abnormality |
|
|
| Aortic Aneurysm, Familial Thoracic 1 |
|
|
| Myopathy |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
| Fundus Dystrophy |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | GAPDH | VGNC | VGNC:97273 |
| Mus musculus | GAPDH | MGD | MGI:95640 |
| Rattus norvegicus | GAPDH | RGD | RGD:2661 |
| Felis catus | GAPDH | VGNC | VGNC:84023 |
| Macaca mulatta | GAPDH | VGNC | VGNC:99930 |
| Others | GAPDH | NCBI |