Nfkbid - nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta Gene

Mus musculus

Also known as IkappaBNS; ikB-delta; I-kappa-B-delta

Gene ID: 243910 | Gene type: protein coding

About Nfkbid

Summary

Enables NF-kappaB binding activity. Involved in T cell receptor signaling pathway and positive regulation of T-helper 17 cell differentiation. Acts upstream of or within several processes, including negative regulation of NF-kappaB transcription factor activity; negative regulation of T cell differentiation in thymus; and positive regulation of thymocyte apoptotic process. Located in nucleus. Orthologous to human NFKBID (NFKB inhibitor delta). [provided by Alliance of Genome Resources, Apr 2022]

Nfkbid Products(3)

mRNA	Protein	Name
NM_001360906.1	NP_001347835.1	NF-kappa-B inhibitor delta
NM_001360907.1	NP_001347836.1	NF-kappa-B inhibitor delta
NM_172142.4	NP_742154.1	NF-kappa-B inhibitor delta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NF-kappaB binding	IPI IPI: Inferred from physical interaction	11931770	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11931770	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of T cell differentiation in thymus	IDA IDA: Inferred from direct assay	11931770	MGI
involved in T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25282160	MGI
acts upstream of or within negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	11931770	MGI
acts upstream of or within negative regulation of T cell differentiation in thymus	IDA IDA: Inferred from direct assay	11931770	MGI
acts upstream of or within negative regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	11931770	MGI
involved in positive regulation of T-helper 17 cell differentiation	IMP IMP: Inferred from mutant phenotype	25282160	MGI
acts upstream of or within positive regulation of thymocyte apoptotic process	IDA IDA: Inferred from direct assay	11931770	MGI
acts upstream of thymocyte apoptotic process	IDA IDA: Inferred from direct assay	11931770	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	11931770	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

NF-kappa-B inhibitor delta

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09262	NFKBID Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nfkbid	NCBI	NCBI:84807

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