Grik5 - glutamate ionotropic receptor kainate type subunit 5 Gene

Also Known as GluK5; iGlu5

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24407

Summary

Enables identical protein binding activity; kainate selective glutamate receptor activity; and protein domain specific binding activity. Involved in several processes, including cellular response to glucose stimulus; positive regulation of neuron apoptotic process; and protein retention in ER lumen. Located in several cellular components, including perikaryon; postsynaptic density; and terminal bouton. Part of ionotropic glutamate receptor complex. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study visual epilepsy. Biomarker of temporal lobe epilepsy. Orthologous to human GRIK5 (glutamate ionotropic receptor kainate type subunit 5). [provided by Alliance of Genome Resources, Apr 2022]

Grik5 Products (1)

mRNA	Protein	Name
NM_031508.2	NP_113696.1	glutamate receptor ionotropic, kainate 5 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	1127911	RGD
enables SH3 domain binding	IMP IMP: Inferred from mutant phenotype	1127911	RGD
enables glutamate receptor activity	IDA IDA: Inferred from direct assay	10627597	RGD
contributes to glutamate-gated receptor activity	IDA IDA: Inferred from direct assay	9254673	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	12878702	RGD
enables kainate selective glutamate receptor activity	IDA IDA: Inferred from direct assay	12080343	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	17639597	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	16936133	RGD
involved in chemical synaptic transmission	IDA IDA: Inferred from direct assay	12080343	RGD
involved in establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	12878702	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	17639597	RGD
involved in protein retention in ER lumen	IMP IMP: Inferred from mutant phenotype	12878702	RGD
involved in receptor clustering	IDA IDA: Inferred from direct assay	9808460	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	15844209	RGD
located in dendrite	IDA IDA: Inferred from direct assay	9808460	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16360275	RGD
part of ionotropic glutamate receptor complex	IDA IDA: Inferred from direct assay	10627597	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	18096442	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	15844209	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	22509486	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	16903873	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	16360275	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	15844209	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
glutamate receptor ionotropic, kainate 5	KA2 glutamate receptor KA-2 glutamate receptor KA2 glutamate receptor, ionotropic, kainate 5

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05802	GRIK5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grik5	NCBI	NCBI:2901