Ppp1ca - protein phosphatase 1 catalytic subunit alpha Gene

Rattus norvegicus

Also known as PP1alpha

Gene ID: 24668 | Gene type: protein coding

About Ppp1ca

Summary

Enables phosphoprotein Phosphatase activity; protein Phosphatase 1 binding activity; and ribonucleoprotein complex binding activity. Involved in protein dephosphorylation; regulation of glycogen metabolic process; and response to lead ion. Located in several cellular components, including dendritic spine; glycogen granule; and perikaryon. Part of protein Phosphatase type 1 complex. Is active in glutamatergic synapse; postsynapse; and presynapse. Orthologous to human PPP1CA (protein Phosphatase 1 catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Ppp1ca Products(1)

mRNA	Protein	Name
NM_031527.1	NP_113715.1	serine/threonine-protein phosphatase PP1-alpha catalytic subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphoprotein phosphatase activity	IDA IDA: Inferred from direct assay	7720853	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10504266	RGD
enables protein phosphatase 1 binding	IPI IPI: Inferred from physical interaction	9275233	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	10504266	RGD
enables ribonucleoprotein complex binding	IPI IPI: Inferred from physical interaction	12065664	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	7720853	RGD
involved in regulation of glycogen biosynthetic process	IDA IDA: Inferred from direct assay	7720853	RGD
involved in regulation of glycogen catabolic process	IDA IDA: Inferred from direct assay	7720853	RGD
involved in response to lead ion	IDA IDA: Inferred from direct assay	22387731	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendritic spine	IDA IDA: Inferred from direct assay	7724573	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	7724573	RGD
located in glycogen granule	IDA IDA: Inferred from direct assay	7720853	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12065664	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	7724573	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	7724573	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	7724573	RGD
part of protein phosphatase type 1 complex	IDA IDA: Inferred from direct assay	7720853	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase PP1-alpha catalytic subunit

PP-1A	Protein phosphatase type 1 alpha, catalytic subunit
protein phosphatase 1, catalytic subunit, alpha isozyme	protein phosphatase-1d

Ppp1ca Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ppp1ca	P62138	Tor1aip1	Rattus norvegicus	Q5PQX1	Anti Bait CoIP	24116158

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10973	PPP1CA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppp1ca	NCBI	NCBI:5499

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