Gimap5 - GTPase, IMAP family member 5 Gene

Rattus norvegicus

Also known as lyp; IAN4; Ian5; Ian4l1

Gene ID: 246774 | Gene type: protein coding

About Gimap5

Summary

Predicted to enable GTP binding activity. Involved in several processes, including mononuclear cell differentiation; positive regulation of lymphocyte mediated immunity; and regulation of T cell activation. Located in mitochondrion. Used to study lymphopenia and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in portal hypertension. Orthologous to several human genes including GIMAP5 (GTPase, IMAP family member 5). [provided by Alliance of Genome Resources, Apr 2022]

Gimap5 Products(2)

mRNA	Protein	Name
NM_001033913.1	NP_001029085.1	GTPase IMAP family member 5 isoform 1
NM_145680.3	NP_663713.1	GTPase IMAP family member 5 isoform 2

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell differentiation	IEP IEP: Inferred from expression pattern	16103028	RGD
involved in T cell homeostasis	IMP IMP: Inferred from mutant phenotype	15328390	RGD
involved in myeloid dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	15922563	RGD
involved in negative regulation of T cell activation	IMP IMP: Inferred from mutant phenotype	16584774	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17599904	RGD
involved in negative regulation of lipid catabolic process	IMP IMP: Inferred from mutant phenotype	18465680	RGD
involved in negative regulation of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	9519713	RGD
involved in negative regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	9243099	RGD
involved in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IMP IMP: Inferred from mutant phenotype	15778366	RGD
involved in positive regulation of calcium ion transport into cytosol	IMP IMP: Inferred from mutant phenotype	19007993	RGD
involved in positive regulation of gamma-delta T cell differentiation	IMP IMP: Inferred from mutant phenotype	11859104	RGD
involved in positive regulation of humoral immune response mediated by circulating immunoglobulin	IMP IMP: Inferred from mutant phenotype	11934565	RGD
involved in positive regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	12930893	RGD
involved in positive regulation of natural killer cell cytokine production	IMP IMP: Inferred from mutant phenotype	15100275	RGD
involved in positive regulation of natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	15100275	RGD
involved in regulation of mitochondrial membrane permeability	IMP IMP: Inferred from mutant phenotype	17655828	RGD
involved in temperature homeostasis	IMP IMP: Inferred from mutant phenotype	17705691	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

GTPase IMAP family member 5

IAN-4	immune associated nucleotide 4 like 1
immunity-associated nucleotide 4 protein	immunity-associated nucleotide 4-like 1 protein
lymphopenia

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W011063	Gly-Phe-β-naphthylamide		99.92%	Unkown
HY-RS05425	GIMAP5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gimap5	NCBI	NCBI:55340

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