Gimap5 - GTPase, IMAP family member 5 Gene

Also Known as lyp; IAN4; Ian5; Ian4l1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 246774

Summary

Predicted to enable GTP binding activity. Involved in several processes, including mononuclear cell differentiation; positive regulation of lymphocyte mediated immunity; and regulation of T cell activation. Located in mitochondrion. Used to study lymphopenia and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in portal hypertension. Orthologous to several human genes including GIMAP5 (GTPase, IMAP family member 5). [provided by Alliance of Genome Resources, Apr 2022]

Gimap5 Products (2)

mRNA Protein Name
NM_001033913.1 NP_001029085.1 GTPase IMAP family member 5 isoform 1
NM_145680.3 NP_663713.1 GTPase IMAP family member 5 isoform 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in T cell differentiation IEP
IEP: Inferred from expression pattern
16103028 RGD
involved in T cell homeostasis IMP
IMP: Inferred from mutant phenotype
15328390 RGD
involved in myeloid dendritic cell differentiation IMP
IMP: Inferred from mutant phenotype
15922563 RGD
involved in negative regulation of T cell activation IMP
IMP: Inferred from mutant phenotype
16584774 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
17599904 RGD
involved in negative regulation of lipid catabolic process IMP
IMP: Inferred from mutant phenotype
18465680 RGD
involved in negative regulation of nitric oxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
9519713 RGD
involved in negative regulation of type II interferon production IMP
IMP: Inferred from mutant phenotype
9243099 RGD
involved in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IMP
IMP: Inferred from mutant phenotype
15778366 RGD
involved in positive regulation of calcium ion transport into cytosol IMP
IMP: Inferred from mutant phenotype
19007993 RGD
involved in positive regulation of gamma-delta T cell differentiation IMP
IMP: Inferred from mutant phenotype
11859104 RGD
involved in positive regulation of humoral immune response mediated by circulating immunoglobulin IMP
IMP: Inferred from mutant phenotype
11934565 RGD
involved in positive regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
12930893 RGD
involved in positive regulation of natural killer cell cytokine production IMP
IMP: Inferred from mutant phenotype
15100275 RGD
involved in positive regulation of natural killer cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
15100275 RGD
involved in regulation of mitochondrial membrane permeability IMP
IMP: Inferred from mutant phenotype
17655828 RGD
involved in temperature homeostasis IMP
IMP: Inferred from mutant phenotype
17705691 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GTPase IMAP family member 5

  • IAN-4

  • immune associated nucleotide 4 like 1

  • immunity-associated nucleotide 4 protein

  • immunity-associated nucleotide 4-like 1 protein

  • lymphopenia

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W011063 Gly-Phe-β-naphthylamide 99.92% Unkown
HY-RS05425 GIMAP5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gimap5 NCBI NCBI:55340