Hsd11b1 - hydroxysteroid 11-beta dehydrogenase 1 Gene

Also Known as LRRGT00065

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25116

Summary

Enables NADP binding activity and steroid binding activity. Involved in several processes, including cellular response to estradiol stimulus; glucocorticoid metabolic process; and regulation of pentose-phosphate shunt. Located in apical part of cell; nuclear membrane; and rough endoplasmic reticulum. Used to study obesity. Biomarker of familial hyperlipidemia; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in cortisone reductase deficiency and cortisone reductase deficiency 2. Orthologous to human HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]

Hsd11b1 Products (1)

mRNA Protein Name
NM_017080.2 NP_058776.2 11-beta-hydroxysteroid dehydrogenase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NADP binding IDA
IDA: Inferred from direct assay
15761036 RGD
enables steroid binding IPI
IPI: Inferred from physical interaction
15761036 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to estradiol stimulus IEP
IEP: Inferred from expression pattern
19380458 RGD
involved in glucocorticoid biosynthetic process IDA
IDA: Inferred from direct assay
12460758 RGD
involved in glucocorticoid catabolic process IDA
IDA: Inferred from direct assay
12460758 RGD
involved in mineralocorticoid metabolic process IDA
IDA: Inferred from direct assay
2808402 RGD
involved in regulation of pentose-phosphate shunt IDA
IDA: Inferred from direct assay
16234247 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
16941667 RGD
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
12810566 RGD
located in nuclear membrane IDA
IDA: Inferred from direct assay
11250946 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

11-beta-hydroxysteroid dehydrogenase 1

corticosteroid 11-beta-dehydrogenase isozyme 1

  • 11-DH

  • 11-beta-HSD1

  • 11-beta-hydroxysteroid dehydrogenase, type 1

  • 11beta-HSD1

  • 7-oxosteroid reductase

  • cortocosteroid 11-beta dehydrogenase

  • hydroxysteroid dehydrogenase, 11 beta type 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-167696 11β-HSD1-IN-16 Inhibitor 99.03% Unkown
HY-RS06387 HSD11B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20631 Hsd11b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27140 Hsd11b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hsd11b1 NCBI NCBI:3290