Hsd11b2 - hydroxysteroid 11-beta dehydrogenase 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25117

Summary

Enables NAD binding activity and steroid binding activity. Involved in several processes, including glucocorticoid metabolic process; regulation of blood volume by renal aldosterone; and response to food. Located in cytoplasm and intracellular membrane-bounded organelle. Biomarker of hypertension; myocardial infarction; obesity; and ureteral obstruction. Human ortholog(s) of this gene implicated in apparent mineralocorticoid excess syndrome; hypertension; inherited metabolic disorder; obesity; and type 1 diabetes mellitus. Orthologous to human HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]

Hsd11b2 Products (1)

mRNA Protein Name
NM_017081.2 NP_058777.1 11-beta-hydroxysteroid dehydrogenase type 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables NAD binding IDA
IDA: Inferred from direct assay
15761036 RGD
enables steroid binding IPI
IPI: Inferred from physical interaction
15761036 RGD
Biological Process GO Annotation Evidence References Source
involved in female pregnancy IEP
IEP: Inferred from expression pattern
19050325 RGD
involved in glucocorticoid metabolic process IDA
IDA: Inferred from direct assay
11755176 RGD
involved in regulation of blood volume by renal aldosterone IMP
IMP: Inferred from mutant phenotype
15718388 RGD
involved in response to food IEP
IEP: Inferred from expression pattern
18548384 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
19490994 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
19470702 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
9495277 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
18032797 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
10792625 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

11-beta-hydroxysteroid dehydrogenase type 2

  • 11-DH2

  • 11-beta-HSD2

  • Hydroxysteroid dehydrogenase, 11 beta type 2

  • NAD-dependent 11-beta-hydroxysteroid dehydrogenase

  • corticosteroid 11-beta-dehydrogenase isozyme 2

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14598 Diethylstilbestrol 99.62% Unkown

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06388 HSD11B2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W744064 Diethylstilbestrol-d4 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hsd11b2 NCBI NCBI:3291