2. Gene
  3. LPCAT4 - lysophosphatidylcholine acyltransferase 4 Gene

LPCAT4 - lysophosphatidylcholine acyltransferase 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AYTL3; AGPAT7; LPEAT2; LPLAT10; LPAAT-eta

Gene ID: 254531 | Gene type: protein coding

About LPCAT4

Cytogenetic location: 15q14 Genomic coordinates (GRCh38): 15:34,358,633-34,367,196 (from NCBI)

This gene has 9 transcripts (splice variants), 195 orthologues and 4 paralogues. Ubiquitous expression in stomach (RPKM 27.5), duodenum (RPKM 20.5) and 23 other tissues.

Summary

Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction (Ye et al., 2005 [PubMed 16243729]).[supplied by OMIM, May 2008]

LPCAT4 Products(1)

mRNA Protein Name
NM_153613.3 NP_705841.2 lysophospholipid acyltransferase LPCAT4

LPCAT4 Protein Structure

Acyltransferase

Acyltransferase: Acyltransferase (108 - 231)

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  • 524 a.a.
Protein Preferred Names Protein Names

lysophospholipid acyltransferase LPCAT4

1-AGP acyltransferase 7

Related Diseases

Diseases Alias
Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract

Pharc Syndrome

PHARC

Polyneyropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract

Polyneuropathy-Hearing Loss-Ataxia-Retinitis Pigmentosa-Cataract Syndrome

Peripheral Neuropathy, Fiskerstrand Type

Polyneuropathy-Deafness-Ataxia-Retinitis Pigmentosa-Cataract Syndrome

Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, Cataract
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07767 LPCAT4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LPCAT4 MGD MGI:2138993
Felis catus LPCAT4 VGNC VGNC:63267
Bos taurus LPCAT4 VGNC VGNC:30964
Canis familiaris LPCAT4 VGNC VGNC:54323
Macaca mulatta LPCAT4 VGNC VGNC:74402
Rattus norvegicus LPCAT4 RGD RGD:1311177