LPCAT4 - lysophosphatidylcholine acyltransferase 4 Gene

Also Known as AYTL3; AGPAT7; LPEAT2; LPLAT10; LPAAT-eta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 254531

About LPCAT4

Cytogenetic location: 15q14 Genomic coordinates (GRCh38): 15:34,358,633-34,367,196 (from NCBI)

This gene has 9 transcripts (splice variants), 195 orthologues and 4 paralogues. Ubiquitous expression in stomach (RPKM 27.5), duodenum (RPKM 20.5) and 23 other tissues.

Summary

Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction (Ye et al., 2005 [PubMed 16243729]).[supplied by OMIM, May 2008]

LPCAT4 Products (1)

mRNA Protein Name
NM_153613.3 NP_705841.2 lysophospholipid acyltransferase LPCAT4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 1-acylglycerophosphocholine O-acyltransferase activity IDA
IDA: Inferred from direct assay
18458083 GOA
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity IDA
IDA: Inferred from direct assay
18458083 GOA
enables 1-acylglycerophosphoserine O-acyltransferase activity IDA
IDA: Inferred from direct assay
18458083 GOA
enables 1-alkenylglycerophosphoethanolamine O-acyltransferase activity IDA
IDA: Inferred from direct assay
18458083 GOA
enables 1-alkylglycerophosphocholine O-acetyltransferase activity IDA
IDA: Inferred from direct assay
18458083 GOA
enables lysophospholipid acyltransferase activity IDA
IDA: Inferred from direct assay
18458083 GOA
enables lysophospholipid acyltransferase activity IMP
IMP: Inferred from mutant phenotype
18458083 GOA
Biological Process GO Annotation Evidence References Source
involved in phosphatidylcholine acyl-chain remodeling IDA
IDA: Inferred from direct assay
18458083 GOA
involved in phosphatidylethanolamine acyl-chain remodeling IDA
IDA: Inferred from direct assay
18458083 GOA
involved in phosphatidylserine acyl-chain remodeling IDA
IDA: Inferred from direct assay
18458083 GOA
acts upstream of or within phospholipid metabolic process IDA
IDA: Inferred from direct assay
18458083 GOA
acts upstream of or within phospholipid metabolic process IMP
IMP: Inferred from mutant phenotype
18458083 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
18458083 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LPCAT4 Protein Structure

Acyltransferase

Acyltransferase: Acyltransferase (108 - 231)

  • 0
  • 100
  • 200
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  • 400
  • 500
  • 524 a.a.
Protein Preferred Names Protein Names

lysophospholipid acyltransferase LPCAT4

  • 1-AGP acyltransferase 7

Related Diseases

Diseases Alias
Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract

  • Pharc Syndrome

  • PHARC

  • Polyneyropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract

  • Polyneuropathy-Hearing Loss-Ataxia-Retinitis Pigmentosa-Cataract Syndrome

  • Peripheral Neuropathy, Fiskerstrand Type

  • Polyneuropathy-Deafness-Ataxia-Retinitis Pigmentosa-Cataract Syndrome

  • Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, Cataract
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08194 MBOAT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07767 LPCAT4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LPCAT4 MGD MGI:2138993
Felis catus LPCAT4 VGNC VGNC:63267
Bos taurus LPCAT4 VGNC VGNC:30964
Canis familiaris LPCAT4 VGNC VGNC:54323
Macaca mulatta LPCAT4 VGNC VGNC:74402
Rattus norvegicus LPCAT4 RGD RGD:1311177
Others LPCAT4 NCBI