Kcna5 - potassium voltage-gated channel subfamily A member 5 Gene

Also Known as Kv1; Kv1.5

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25470

Summary

Enables delayed rectifier Potassium Channel activity; outward rectifier Potassium Channel activity; and signaling receptor binding activity. Involved in several processes, including metal ion homeostasis; positive regulation of G1/S transition of mitotic cell cycle; and potassium ion export across plasma membrane. Located in several cellular components, including Z disc; intercalated disc; and intracellular canaliculus. Is integral component of plasma membrane. Part of voltage-gated Potassium Channel complex. Used to study pulmonary hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in familial atrial fibrillation and pulmonary hypertension. Orthologous to human KCNA5 (potassium voltage-gated channel subfamily A member 5). [provided by Alliance of Genome Resources, Apr 2022]

Kcna5 Products (1)

mRNA	Protein	Name
NM_012972.2	NP_037104.1	potassium voltage-gated channel subfamily A member 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables delayed rectifier potassium channel activity	IDA IDA: Inferred from direct assay	15618540	RGD
enables outward rectifier potassium channel activity	IMP IMP: Inferred from mutant phenotype	12127166	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16527989	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	16527989	RGD
enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	2361015	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	15151918	RGD
involved in positive regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	18230363	RGD
involved in positive regulation of myoblast proliferation	IDA IDA: Inferred from direct assay	18230363	RGD
involved in potassium ion export across plasma membrane	IMP IMP: Inferred from mutant phenotype	12127166	RGD
involved in potassium ion homeostasis	IMP IMP: Inferred from mutant phenotype	12127166	RGD
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	15618540	RGD
involved in protein complex oligomerization	IMP IMP: Inferred from mutant phenotype	12127166	RGD
involved in regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	18230363	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	16735674	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	16735674	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	15151918	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	17293496	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in Z disc	IDA IDA: Inferred from direct assay	17054951	RGD
located in intercalated disc	IDA IDA: Inferred from direct assay	20357183	RGD
located in intracellular canaliculus	IDA IDA: Inferred from direct assay	17496801	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	17496801	RGD
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	15618540	RGD
part of potassium channel complex	IDA IDA: Inferred from direct assay	9334400	RGD
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	15618540	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
potassium voltage-gated channel subfamily A member 5	Potassium (K+) channel protein alpha 5 RCK7 RK4 potassium channel, voltage gated shaker related subfamily A, member 5 potassium voltage-gated channel, shaker-related subfamily, member 5 voltage-gated potassium channel subunit Kv1.5

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07101	KCNA5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcna5	NCBI	NCBI:3741