USP49 - ubiquitin specific peptidase 49 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25862

About USP49

This gene has 6 transcripts (splice variants), 206 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 2.1), thyroid (RPKM 1.8) and 25 other tissues.

Summary

Enables cysteine-type endopeptidase activity; histone binding activity; and thiol-dependent Deubiquitinase. Involved in histone H2B conserved C-terminal lysine deubiquitination and mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

USP49 Products (3)

mRNA Protein Name
NM_001286554.2 NP_001273483.1 ubiquitin carboxyl-terminal hydrolase 49 isoform a
NM_001384542.1 NP_001371471.1 ubiquitin carboxyl-terminal hydrolase 49 isoform a
NM_018561.5 NP_061031.2 ubiquitin carboxyl-terminal hydrolase 49 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
14715245 GOA
enables cysteine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
23824326 GOA
enables histone H2B deubiquitinase activity IDA
IDA: Inferred from direct assay
23824326 GOA
enables histone binding IDA
IDA: Inferred from direct assay
23824326 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19615732 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
23824326 GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
28363942 GOA
involved in protein deubiquitination IDA
IDA: Inferred from direct assay
28363942 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP49 Protein Structure

zf-UBP

zf-UBP: Zn-finger in ubiquitin-hydrolases and other protein (26 - 87)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (252 - 654)

  • 0
  • 200
  • 400
  • 600
  • 688 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 49

  • deubiquitinating enzyme 49

USP49 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
USP49 Q70CQ1 FKBP5 Homo sapiens Q13451
Anti Tag CoIP
19615732
Intra
USP49 Q70CQ1 FKBP5 Homo sapiens Q13451
Lumier
25036637
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15560 USP49 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20513 Usp49 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27022 Usp49 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris USP49 VGNC VGNC:48200
Bos taurus USP49 VGNC VGNC:36734
Felis catus USP49 VGNC VGNC:66892
Mus musculus USP49 MGD MGI:2685391
Rattus norvegicus USP49 RGD RGD:1310513
Macaca mulatta USP49 VGNC VGNC:79231
Others USP49 NCBI