Map2k3 - mitogen-activated protein kinase kinase 3 Gene

Also Known as MEK3; MKK3; MKK3b; Prkmk3; MAPKK 3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26397

Summary

Enables MAP kinase kinase activity and protein kinase binding activity. Acts upstream of or within several processes, including MAPK cascade; cardiac muscle contraction; and positive regulation of MAPK cascade. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in cervical Cancer and restrictive cardiomyopathy. Orthologous to human MAP2K3 (mitogen-activated protein kinase kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Map2k3 Products (1)

mRNA Protein Name
NM_008928.5 NP_032954.1 dual specificity mitogen-activated protein kinase kinase 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables MAP kinase kinase activity IDA
IDA: Inferred from direct assay
8900184 MGI
enables MAP kinase kinase activity IMP
IMP: Inferred from mutant phenotype
10097111 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17438131 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
18948261 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within MAPK cascade IDA
IDA: Inferred from direct assay
8900184 MGI
acts upstream of or within MAPK cascade IMP
IMP: Inferred from mutant phenotype
10097111 MGI
acts upstream of or within cardiac muscle contraction IMP
IMP: Inferred from mutant phenotype
11593045 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
10097111 MGI
acts upstream of or within positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
15767678 MGI
acts upstream of or within positive regulation of MAPK cascade IGI
IGI: Inferred from genetic interaction
15767678 MGI
acts upstream of or within regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
10097111 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dual specificity mitogen-activated protein kinase kinase 3

  • MAP kinase kinase 3

  • MAPK/ERK kinase 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08039 MAP2K3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map2k3 NCBI NCBI:5606