Map2k3 - mitogen-activated protein kinase kinase 3 Gene

Mus musculus

Also known as MEK3; MKK3; MKK3b; Prkmk3; MAPKK 3

Gene ID: 26397 | Gene type: protein coding

About Map2k3

Summary

Enables MAP kinase kinase activity and protein kinase binding activity. Acts upstream of or within several processes, including MAPK cascade; cardiac muscle contraction; and positive regulation of MAPK cascade. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in cervical Cancer and restrictive cardiomyopathy. Orthologous to human MAP2K3 (mitogen-activated protein kinase kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Map2k3 Products(1)

mRNA	Protein	Name
NM_008928.5	NP_032954.1	dual specificity mitogen-activated protein kinase kinase 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables MAP kinase kinase activity	IDA IDA: Inferred from direct assay	8900184	MGI
enables MAP kinase kinase activity	IMP IMP: Inferred from mutant phenotype	10097111	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17438131	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	18948261	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within MAPK cascade	IDA IDA: Inferred from direct assay	8900184	MGI
acts upstream of or within MAPK cascade	IMP IMP: Inferred from mutant phenotype	10097111	MGI
acts upstream of or within cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	11593045	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	10097111	MGI
acts upstream of or within positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	15767678	MGI
acts upstream of or within positive regulation of MAPK cascade	IGI IGI: Inferred from genetic interaction	15767678	MGI
acts upstream of or within regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	10097111	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dual specificity mitogen-activated protein kinase kinase 3

MAP kinase kinase 3

MAPK/ERK kinase 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08039	MAP2K3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map2k3	NCBI	NCBI:5606

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