Nherf1 - NHERF family PDZ scaffold protein 1 Gene

Also Known as EBP-50; NHE-RF; NHERF-1; Slc9a3r1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26941

Summary

Enables Dopamine Receptor binding activity and Phosphatase binding activity. Involved in several processes, including maintenance of epithelial cell apical/basal polarity; negative regulation of signal transduction; and organic anion transport. Acts upstream of or within several processes, including auditory receptor cell stereocilium organization; cellular phosphate ion homeostasis; and Dopamine Receptor signaling pathway. Located in several cellular components, including brush border membrane; sperm midpiece; and stereocilium tip. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; pleura; and sensory organ. Human ortholog(s) of this gene implicated in hypophosphatemic nephrolithiasis/osteoporosis 2. Orthologous to human SLC9A3R1 (SLC9A3 regulator 1). [provided by Alliance of Genome Resources, Apr 2022]

Nherf1 Products (1)

mRNA Protein Name
NM_012030.2 NP_036160.1 Na(+)/H(+) exchange regulatory cofactor NHE-RF1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables dopamine receptor binding IDA
IDA: Inferred from direct assay
20200151 MGI
enables phosphatase binding IPI
IPI: Inferred from physical interaction
16456542 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12780527 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
15591354 MGI
acts upstream of or within adenylate cyclase-activating dopamine receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
20200151 MGI
acts upstream of or within auditory receptor cell stereocilium organization IMP
IMP: Inferred from mutant phenotype
24920589 MGI
involved in bile acid secretion IMP
IMP: Inferred from mutant phenotype
20404332 MGI
acts upstream of or within cerebrospinal fluid circulation IDA
IDA: Inferred from direct assay
28392297 MGI
acts upstream of or within cerebrospinal fluid circulation IMP
IMP: Inferred from mutant phenotype
25775275 MGI
involved in cilium organization IMP
IMP: Inferred from mutant phenotype
25775275 MGI
acts upstream of establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
12586353 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
12586353 MGI
acts upstream of fibroblast migration IGI
IGI: Inferred from genetic interaction
16456542 MGI
involved in glutathione transport IMP
IMP: Inferred from mutant phenotype
20404332 MGI
acts upstream of or within intracellular phosphate ion homeostasis IMP
IMP: Inferred from mutant phenotype
12169661 MGI
involved in maintenance of epithelial cell apical/basal polarity IMP
IMP: Inferred from mutant phenotype
25775275 MGI
involved in negative regulation of cell motility IMP
IMP: Inferred from mutant phenotype
16456542 MGI
acts upstream of or within negative regulation of fibroblast migration IGI
IGI: Inferred from genetic interaction
16456542 MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
16456542 MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
16456542 MGI
involved in negative regulation of platelet-derived growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
18190691 MGI
acts upstream of or within negative regulation of sodium ion transport IMP
IMP: Inferred from mutant phenotype
12586353 MGI
acts upstream of or within negative regulation of sodium:proton antiporter activity IMP
IMP: Inferred from mutant phenotype
12586353 MGI
acts upstream of or within phospholipase C-activating dopamine receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
20200151 MGI
involved in plasma membrane organization IMP
IMP: Inferred from mutant phenotype
25775275 MGI
acts upstream of or within protein localization IMP
IMP: Inferred from mutant phenotype
12952857 MGI
involved in regulation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
18190691 MGI
acts upstream of or within regulation of renal phosphate excretion IMP
IMP: Inferred from mutant phenotype
12952857 MGI
involved in renal absorption IMP
IMP: Inferred from mutant phenotype
12169661 MGI
acts upstream of or within renal sodium ion transport IMP
IMP: Inferred from mutant phenotype
12586353 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
24920589 MGI
acts upstream of sodium ion transport IMP
IMP: Inferred from mutant phenotype
12586353 MGI
Cellular Component GO Annotation Evidence Références Source
located in apical part of cell IDA
IDA: Inferred from direct assay
14996907 MGI
located in apical plasma membrane IDA
IDA: Inferred from direct assay
12169661 MGI
located in brush border membrane IDA
IDA: Inferred from direct assay
15591354 MGI
located in membrane IDA
IDA: Inferred from direct assay
19857202 MGI
located in sperm midpiece IDA
IDA: Inferred from direct assay
21976599 MGI
located in stereocilium IDA
IDA: Inferred from direct assay
24920589 MGI
located in stereocilium tip IDA
IDA: Inferred from direct assay
24920589 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

Na(+)/H(+) exchange regulatory cofactor NHE-RF1

  • EBP50

  • ezrin-radixin-moesin-binding phosphoprotein 50

  • regulatory cofactor of Na(+)/H(+) exchanger

  • sodium-hydrogen exchanger regulatory factor 1

  • solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-150269 RS5517 Inhibitor 95.79% Unkown
HY-182624 FJ9 / Unkown
HY-RS09282 NHERF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P10226 PGD97 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nherf1 NCBI NCBI:9368