Nherf1 - NHERF family PDZ scaffold protein 1 Gene

Mus musculus

Also known as EBP-50; NHE-RF; NHERF-1; Slc9a3r1

Gene ID: 26941 | Gene type: protein coding

About Nherf1

Summary

Enables Dopamine Receptor binding activity and Phosphatase binding activity. Involved in several processes, including maintenance of epithelial cell apical/basal polarity; negative regulation of signal transduction; and organic anion transport. Acts upstream of or within several processes, including auditory receptor cell stereocilium organization; cellular phosphate ion homeostasis; and Dopamine Receptor signaling pathway. Located in several cellular components, including brush border membrane; sperm midpiece; and stereocilium tip. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; pleura; and sensory organ. Human ortholog(s) of this gene implicated in hypophosphatemic nephrolithiasis/osteoporosis 2. Orthologous to human SLC9A3R1 (SLC9A3 regulator 1). [provided by Alliance of Genome Resources, Apr 2022]

Nherf1 Products(1)

mRNA	Protein	Name
NM_012030.2	NP_036160.1	Na(+)/H(+) exchange regulatory cofactor NHE-RF1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables dopamine receptor binding	IDA IDA: Inferred from direct assay	20200151	MGI
enables phosphatase binding	IPI IPI: Inferred from physical interaction	16456542	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12780527	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	15591354	MGI
acts upstream of or within adenylate cyclase-activating dopamine receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20200151	MGI
acts upstream of or within auditory receptor cell stereocilium organization	IMP IMP: Inferred from mutant phenotype	24920589	MGI
involved in bile acid secretion	IMP IMP: Inferred from mutant phenotype	20404332	MGI
acts upstream of or within cerebrospinal fluid circulation	IDA IDA: Inferred from direct assay	28392297	MGI
acts upstream of or within cerebrospinal fluid circulation	IMP IMP: Inferred from mutant phenotype	25775275	MGI
involved in cilium organization	IMP IMP: Inferred from mutant phenotype	25775275	MGI
acts upstream of establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	12586353	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	12586353	MGI
acts upstream of fibroblast migration	IGI IGI: Inferred from genetic interaction	16456542	MGI
involved in glutathione transport	IMP IMP: Inferred from mutant phenotype	20404332	MGI
acts upstream of or within intracellular phosphate ion homeostasis	IMP IMP: Inferred from mutant phenotype	12169661	MGI
involved in maintenance of epithelial cell apical/basal polarity	IMP IMP: Inferred from mutant phenotype	25775275	MGI
involved in negative regulation of cell motility	IMP IMP: Inferred from mutant phenotype	16456542	MGI
acts upstream of or within negative regulation of fibroblast migration	IGI IGI: Inferred from genetic interaction	16456542	MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: Inferred from genetic interaction	16456542	MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	16456542	MGI
involved in negative regulation of platelet-derived growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18190691	MGI
acts upstream of or within negative regulation of sodium ion transport	IMP IMP: Inferred from mutant phenotype	12586353	MGI
acts upstream of or within negative regulation of sodium:proton antiporter activity	IMP IMP: Inferred from mutant phenotype	12586353	MGI
acts upstream of or within phospholipase C-activating dopamine receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20200151	MGI
involved in plasma membrane organization	IMP IMP: Inferred from mutant phenotype	25775275	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	12952857	MGI
involved in regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	18190691	MGI
acts upstream of or within regulation of renal phosphate excretion	IMP IMP: Inferred from mutant phenotype	12952857	MGI
involved in renal absorption	IMP IMP: Inferred from mutant phenotype	12169661	MGI
acts upstream of or within renal sodium ion transport	IMP IMP: Inferred from mutant phenotype	12586353	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	24920589	MGI
acts upstream of sodium ion transport	IMP IMP: Inferred from mutant phenotype	12586353	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	14996907	MGI
located in apical plasma membrane	IDA IDA: Inferred from direct assay	12169661	MGI
located in brush border membrane	IDA IDA: Inferred from direct assay	15591354	MGI
located in membrane	IDA IDA: Inferred from direct assay	19857202	MGI
located in sperm midpiece	IDA IDA: Inferred from direct assay	21976599	MGI
located in stereocilium	IDA IDA: Inferred from direct assay	24920589	MGI
located in stereocilium tip	IDA IDA: Inferred from direct assay	24920589	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

Na(+)/H(+) exchange regulatory cofactor NHE-RF1

EBP50	ezrin-radixin-moesin-binding phosphoprotein 50
regulatory cofactor of Na(+)/H(+) exchanger	sodium-hydrogen exchanger regulatory factor 1
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150269	RS5517	Inhibitor	95.79%	Unkown
HY-182624	FJ9		/	Unkown
HY-RS09282	NHERF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P10226	PGD97		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nherf1	NCBI	NCBI:9368

Name
Email *

	Sorry, but the email address you supplied was invalid.