Spo11 - SPO11 initiator of meiotic double stranded breaks Gene

Also Known as Spo11a; Spo11b

Species: Mus musculus

Gene Type: protein coding

Gene ID: 26972

Summary

Predicted to enable DNA binding activity. Acts upstream of or within several processes, including germ cell development; meiosis I; and ovarian follicle development. Located in chromosome, telomeric region. Is expressed in several structures, including gonad; hemolymphoid system gland; liver; oral epithelium; and skin. Orthologous to human SPO11 (SPO11 initiator of meiotic double stranded breaks). [provided by Alliance of Genome Resources, Apr 2022]

Spo11 Products (5)

mRNA	Protein	Name
NM_001083959.1	NP_001077428.1	meiotic recombination protein SPO11 isoform c
NM_001083960.1	NP_001077429.1	meiotic recombination protein SPO11 isoform b
NM_001305434.1	NP_001292363.1	meiotic recombination protein SPO11 isoform d
NM_001412470.1	NP_001399399.1	meiotic recombination protein SPO11 isoform e
NM_012046.2	NP_036176.1	meiotic recombination protein SPO11 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	26917764	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within double-strand break repair involved in meiotic recombination	IGI IGI: Inferred from genetic interaction	27760146	MGI
acts upstream of or within homologous chromosome pairing at meiosis	IMP IMP: Inferred from mutant phenotype	18694567	MGI
acts upstream of or within leptotene	IMP IMP: Inferred from mutant phenotype	17010969	MGI
acts upstream of or within male meiosis I	IMP IMP: Inferred from mutant phenotype	17696610	MGI
acts upstream of or within meiotic telomere clustering	IMP IMP: Inferred from mutant phenotype	17010969	MGI
acts upstream of or within oogenesis	IMP IMP: Inferred from mutant phenotype	22530760	MGI
acts upstream of or within ovarian follicle development	IMP IMP: Inferred from mutant phenotype	15640358	MGI
acts upstream of or within protein localization to chromosome	IMP IMP: Inferred from mutant phenotype	20551173	MGI
acts upstream of or within reciprocal meiotic recombination	IMP IMP: Inferred from mutant phenotype	16307920	MGI
acts upstream of or within spermatid development	IMP IMP: Inferred from mutant phenotype	17696610	MGI
acts upstream of or within synaptonemal complex assembly	IGI IGI: Inferred from genetic interaction	24589552	MGI
acts upstream of or within synaptonemal complex assembly	IMP IMP: Inferred from mutant phenotype	27760146	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	20336070	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
meiotic recombination protein SPO11	SPO11 meiotic protein covalently bound to DSB homolog sporulation protein, meiosis-specific, SPO11 homolog (S. cervisiae)

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13693	SPO11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Spo11	NCBI	NCBI:23626