2. Gene
  3. Spo11 - SPO11 initiator of meiotic double stranded breaks Gene

Spo11 - SPO11 initiator of meiotic double stranded breaks Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Spo11a; Spo11b

Gene ID: 26972 | Gene type: protein coding

About Spo11

Summary

Predicted to enable DNA binding activity. Acts upstream of or within several processes, including germ cell development; meiosis I; and ovarian follicle development. Located in chromosome, telomeric region. Is expressed in several structures, including gonad; hemolymphoid system gland; liver; oral epithelium; and skin. Orthologous to human SPO11 (SPO11 initiator of meiotic double stranded breaks). [provided by Alliance of Genome Resources, Apr 2022]

Spo11 Products(5)

mRNA Protein Name
NM_001083959.1 NP_001077428.1 meiotic recombination protein SPO11 isoform c
NM_001083960.1 NP_001077429.1 meiotic recombination protein SPO11 isoform b
NM_001305434.1 NP_001292363.1 meiotic recombination protein SPO11 isoform d
NM_001412470.1 NP_001399399.1 meiotic recombination protein SPO11 isoform e
NM_012046.2 NP_036176.1 meiotic recombination protein SPO11 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
26917764 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within double-strand break repair involved in meiotic recombination IGI
IGI: Inferred from genetic interaction
27760146 MGI
acts upstream of or within homologous chromosome pairing at meiosis IMP
IMP: Inferred from mutant phenotype
18694567 MGI
acts upstream of or within leptotene IMP
IMP: Inferred from mutant phenotype
17010969 MGI
acts upstream of or within male meiosis I IMP
IMP: Inferred from mutant phenotype
17696610 MGI
acts upstream of or within meiotic telomere clustering IMP
IMP: Inferred from mutant phenotype
17010969 MGI
acts upstream of or within oogenesis IMP
IMP: Inferred from mutant phenotype
22530760 MGI
acts upstream of or within ovarian follicle development IMP
IMP: Inferred from mutant phenotype
15640358 MGI
acts upstream of or within protein localization to chromosome IMP
IMP: Inferred from mutant phenotype
20551173 MGI
acts upstream of or within reciprocal meiotic recombination IMP
IMP: Inferred from mutant phenotype
16307920 MGI
acts upstream of or within spermatid development IMP
IMP: Inferred from mutant phenotype
17696610 MGI
acts upstream of or within synaptonemal complex assembly IGI
IGI: Inferred from genetic interaction
24589552 MGI
acts upstream of or within synaptonemal complex assembly IMP
IMP: Inferred from mutant phenotype
27760146 MGI
Cellular Component GO Annotation Evidence Reference Source
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
20336070 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

meiotic recombination protein SPO11

SPO11 meiotic protein covalently bound to DSB homolog

sporulation protein, meiosis-specific, SPO11 homolog (S. cervisiae)

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13693 SPO11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spo11 NCBI NCBI:23626