2. Gene
  3. Chsy1 - chondroitin sulfate synthase 1 Gene

Chsy1 - chondroitin sulfate synthase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as skt

Gene ID: 269941 | Gene type: protein coding

About Chsy1

Summary

Enables Glycosyltransferase activity. Acts upstream of or within several processes, including chondroitin sulfate biosynthetic process; positive regulation of smoothened signaling pathway; and skeletal system development. Predicted to be located in extracellular region. Is expressed in several structures, including alimentary system; brain; cranium; ear; and respiratory system. Human ortholog(s) of this gene implicated in temtamy preaxial brachydactyly syndrome. Orthologous to human CHSY1 (chondroitin sulfate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]

Chsy1 Products(1)

mRNA Protein Name
NM_001081163.2 NP_001074632.1 chondroitin sulfate synthase 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity IGI
IGI: Inferred from genetic interaction
22952769 MGI
enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IGI
IGI: Inferred from genetic interaction
22952769 MGI
enables glycosyltransferase activity IMP
IMP: Inferred from mutant phenotype
22952769 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within bone morphogenesis IMP
IMP: Inferred from mutant phenotype
22280990 MGI
acts upstream of or within cartilage development IMP
IMP: Inferred from mutant phenotype
22280990 MGI
acts upstream of or within chondrocyte development IMP
IMP: Inferred from mutant phenotype
22280990 MGI
acts upstream of or within chondroitin sulfate biosynthetic process IGI
IGI: Inferred from genetic interaction
22952769 MGI
involved in chondroitin sulfate biosynthetic process IGI
IGI: Inferred from genetic interaction
22952769 MGI
acts upstream of or within positive regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
22280990 MGI
acts upstream of or within proximal/distal pattern formation IMP
IMP: Inferred from mutant phenotype
22280990 MGI
acts upstream of or within sulfation IMP
IMP: Inferred from mutant phenotype
22280990 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in Golgi apparatus IDA
IDA: Inferred from direct assay
6781479 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

chondroitin sulfate synthase 1

N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1

N-acetylgalactosaminyltransferase 1

carbohydrate (chondroitin) synthase 1

chondroitin glucuronyltransferase 1

glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactos

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02695 CHSY1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chsy1 NCBI NCBI:22856