CACNG4 - calcium voltage-gated channel auxiliary subunit gamma 4 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27092

About CACNG4

Cytogenetic location: 17q24.2 Genomic coordinates (GRCh38): 17:66,964,707-67,033,398 (from NCBI)

This gene has 1 transcript (splice variant), 257 orthologues and 5 paralogues. Biased expression in brain (RPKM 19.4), prostate (RPKM 8.2) and 1 other tissue.

Summary

The protein encoded by this gene is a type I transmembrane AMPA Receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a Calcium Channel gamma subunit. [provided by RefSeq, Dec 2010]

CACNG4 Products (1)

mRNA Protein Name
NM_014405.4 NP_055220.1 voltage-dependent calcium channel gamma-4 subunit

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium channel regulator activity IDA
IDA: Inferred from direct assay
21127204 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of AMPA receptor activity IDA
IDA: Inferred from direct assay
21172611 GOA
Cellular Component GO Annotation Evidence References Source
part of L-type voltage-gated calcium channel complex IDA
IDA: Inferred from direct assay
21127204 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CACNG4 Protein Structure

PMP22_Claudin

PMP22_Claudin: PMP-22/EMP/MP20/Claudin family (7 - 202)

  • 0
  • 100
  • 200
  • 300
  • 327 a.a.
Protein Preferred Names Protein Names

voltage-dependent calcium channel gamma-4 subunit

  • TARP gamma-4

Related Diseases

Diseases Alias
Arrhythmogenic Right Ventricular Cardiomyopathy

  • Arrhythmogenic Right Ventricular Dysplasia

  • Arvc

  • Arvd

  • Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

  • Arvc Cardiomyopathy

  • Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia

  • Arvd/C

  • Right Ventricular Dysplasia, Arrhythmogenic

  • Ventricular Dysplasia, Right, Arrhythmogenic

  • Cardiomyopathy, Ventricular, Right, Arrhythmogenic

  • Dysplasia, Arrhythmogenic Right Ventricular
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01812 CACNG4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CACNG4 RGD RGD:628804
Mus musculus CACNG4 MGD MGI:1859167
Macaca mulatta CACNG4 VGNC VGNC:104588
Bos taurus CACNG4 VGNC VGNC:26689
Felis catus CACNG4 VGNC VGNC:98776
Others CACNG4 NCBI