TJP3 - tight junction protein 3 Gene

Homo sapiens

Also known as ZO3; ZO-3

Gene ID: 27134 | Gene type: protein coding

About TJP3

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,708,384-3,750,813 (from NCBI)

This gene has 9 transcripts (splice variants), 201 orthologues and 3 paralogues. Biased expression in colon (RPKM 22.4), duodenum (RPKM 17.0) and 13 other tissues.

Summary

The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin Cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1. [provided by RefSeq, May 2012]

TJP3 Products(2)

mRNA	Protein	Name
NM_001267560.2	NP_001254489.1	tight junction protein ZO-3 isoform 1
NM_001267561.2	NP_001254490.1	tight junction protein ZO-3 isoform 2

TJP3 Protein Structure

PDZ

SH3_2

Guanylate_kin

0
200
400
600
800
919 a.a.

Protein Preferred Names

Protein Names

tight junction protein ZO-3

tight junction protein 3 (zona occludens 3)

Related Diseases

Diseases

Alias

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14555	TJP3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TJP3	VGNC	VGNC:66200
Mus musculus	TJP3	MGD	MGI:1351650
Rattus norvegicus	TJP3	RGD	RGD:1309247
Canis familiaris	TJP3	VGNC	VGNC:47388
Bos taurus	TJP3	VGNC	VGNC:35883