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TJP3 - tight junction protein 3 Gene

Also Known as ZO3; ZO-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27134

About TJP3

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,708,384-3,750,813 (from NCBI)

This gene has 9 transcripts (splice variants), 201 orthologues and 3 paralogues. Biased expression in colon (RPKM 22.4), duodenum (RPKM 17.0) and 13 other tissues.

Summary

The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin Cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during Mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1. [provided by RefSeq, May 2012]

TJP3 Products (2)

mRNA	Protein	Name
NM_001267560.2	NP_001254489.1	tight junction protein ZO-3 isoform 1
NM_001267561.2	NP_001254490.1	tight junction protein ZO-3 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18823282	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in bicellular tight junction	IDA IDA: Inferred from direct assay	18823282	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18823282	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TJP3 Protein Structure

PDZ

SH3_2

Guanylate_kin

0
200
400
600
800
919 a.a.

Protein Preferred Names	Protein Names
tight junction protein ZO-3	tight junction protein 3 (zona occludens 3)

TJP3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82711	Tight Junction Protein ZO 3 Antibody (YA2456)	WB	Human, Rat
HY-P82711A	Tight Junction Protein ZO 3 Antibody (YA2456)(PBS only)	WB	Human, Rat

Related Diseases

Diseases	Alias
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14555	TJP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TJP3	VGNC	VGNC:66200
Mus musculus	TJP3	MGD	MGI:1351650
Rattus norvegicus	TJP3	RGD	RGD:1309247
Canis familiaris	TJP3	VGNC	VGNC:47388
Bos taurus	TJP3	VGNC	VGNC:35883
Others	TJP3	NCBI