Sytl4 - synaptotagmin-like 4 Gene

Also Known as Gph; Slp4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 27359

Summary

Enables neurexin family protein binding activity and phospholipid binding activity. Acts upstream of or within exocytosis and negative regulation of Insulin secretion. Located in secretory granule. Is extrinsic component of membrane. Is expressed in diencephalon lateral wall ventricular layer; endocrine gland; foregut-midgut junction; and paravertebral ganglion. Orthologous to human SYTL4 (synaptotagmin like 4). [provided by Alliance of Genome Resources, Apr 2022]

Sytl4 Products (4)

mRNA Protein Name
NM_001290717.1 NP_001277646.1 synaptotagmin-like protein 4 isoform 2
NM_001290718.1 NP_001277647.1 synaptotagmin-like protein 4 isoform 2
NM_001290719.1 NP_001277648.1 synaptotagmin-like protein 4 isoform 3
NM_013757.2 NP_038785.1 synaptotagmin-like protein 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables neurexin family protein binding IDA
IDA: Inferred from direct assay
11243866 MGI
enables phospholipid binding IDA
IDA: Inferred from direct assay
10497219 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11773082 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within exocytosis IDA
IDA: Inferred from direct assay
12590134 MGI
acts upstream of insulin secretion IMP
IMP: Inferred from mutant phenotype
16890542 MGI
acts upstream of or within negative regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
16890542 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
11243866 MGI
located in secretory granule IDA
IDA: Inferred from direct assay
10497219 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

synaptotagmin-like protein 4

  • exophilin-2

  • granuphilin-a

  • granuphilin-b

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14125 SYTL4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sytl4 NCBI NCBI:94121