Trpa1 - transient receptor potential cation channel, subfamily A, member 1 Gene

Also Known as Anktm1; TRPA1b

Species: Mus musculus

Gene Type: protein coding
Gene ID: 277328

Summary

Enables Calcium Channel activity. Involved in several processes, including cell surface receptor signaling pathway; cellular calcium ion homeostasis; and response to organic cyclic compound. Acts upstream of or within several processes, including detection of stimulus involved in sensory perception of pain; response to hydrogen peroxide; and thermoception. Located in stereocilium bundle. Is expressed in cochlea and glossopharyngeal ganglion. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 1. Orthologous to human TRPA1 (transient receptor potential cation channel subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Trpa1 Products (2)

mRNA Protein Name
NM_001348288.1 NP_001335217.1 transient receptor potential cation channel subfamily A member 1 isoform 2
NM_177781.5 NP_808449.1 transient receptor potential cation channel subfamily A member 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium channel activity IDA
IDA: Inferred from direct assay
12654248 MGI
enables calcium channel activity IMP
IMP: Inferred from mutant phenotype
18398506 MGI
enables channel activity IDA
IDA: Inferred from direct assay
15483558 MGI
enables monoatomic ion channel activity IDA
IDA: Inferred from direct assay
15843607 MGI
enables monoatomic ion channel activity IMP
IMP: Inferred from mutant phenotype
15483558 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
25640077 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within calcium ion transport IDA
IDA: Inferred from direct assay
17588549 MGI
acts upstream of or within calcium ion transport IMP
IMP: Inferred from mutant phenotype
18398506 MGI
involved in cell surface receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
25605129 MGI
acts upstream of or within detection of chemical stimulus involved in sensory perception of pain IDA
IDA: Inferred from direct assay
18272293 MGI
acts upstream of or within detection of chemical stimulus involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
16564016 MGI
involved in detection of mechanical stimulus involved in sensory perception IMP
IMP: Inferred from mutant phenotype
25101983 MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
16630838 MGI
acts upstream of or within response to cold IDA
IDA: Inferred from direct assay
12654248 MGI
acts upstream of or within response to cold IMP
IMP: Inferred from mutant phenotype
16630838 MGI
acts upstream of or within response to hydrogen peroxide IMP
IMP: Inferred from mutant phenotype
18398506 MGI
involved in response to organic cyclic compound IMP
IMP: Inferred from mutant phenotype
25605129 MGI
acts upstream of or within response to pain IDA
IDA: Inferred from direct assay
18272293 MGI
acts upstream of or within response to pain IMP
IMP: Inferred from mutant phenotype
16630838 MGI
acts upstream of or within response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
18272293 MGI
acts upstream of or within thermoception IDA
IDA: Inferred from direct assay
12654248 MGI
Cellular Component GO Annotation Evidence References Source
located in stereocilium bundle IDA
IDA: Inferred from direct assay
15483558 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transient receptor potential cation channel subfamily A member 1

  • ankyrin-like with transmembrane domains protein 1

  • wasabi receptor

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-109061 Lazertinib Activator 99.87% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-171846 LY3526318 Inhibitor 99.92% Phase 2
HY-115877 GDC-0334 Antagonist / Phase 1

Pre-clinical Phase

Bioactive Molecules (28)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107436 LE135 Activator 99.0% Unkown
HY-W014421 AP-18 Inhibitor 99.61% Unkown
HY-109061B Lazertinib mesylate Activator 99.85% Unkown
HY-15065 Chembridge-5861528 Antagonist 99.12% Unkown
HY-120689 PF-04745637 Antagonist 99.60% Unkown
HY-N10319 Artepillin C Agonist 99.07% Unkown
HY-N7117 1,4-Cineole Activator 95.0% Unkown
HY-107535 AS1269574 Activator 99.84% Unkown
HY-P1073 ProTx-I Inhibitor 95.15% Unkown
HY-153711 TRPA1-IN-2 Inhibitor 99.55% Unkown
HY-172774 TRPV1 antagonist 10 Antagonist 98.54% Unkown
HY-175980 TRPA1 agonist-3 Agonist 99.78% Unkown
HY-15058 AMG2504 Antagonist / Unkown
HY-109061A Lazertinib mesylate hydrate Activator / Unkown
HY-179432 Cannabitwinol Modulator / Unkown
HY-N7965 Methyl kakuol Agonist / Unkown
HY-170652 ZQMT-10 Inhibitor / Unkown
HY-104062 AMG9678 Antagonist / Unkown
HY-162856 TRPV1-IN-2 Inhibitor / Unkown
HY-104061 AMG8788 Antagonist / Unkown
HY-127003 Neoambrosin Agonist / Unkown
HY-122692 TRPV4/TRPA1-IN-1 Inhibitor / Unkown
HY-181762 Multitarget AD-IN-6 Inhibitor / Unkown
HY-113488 8,9-Epoxyeicosatrienoic acid / Unkown
HY-187167 TRPA1-IN-5 Inhibitor / Unkown
HY-159134 TRPA1-IN-3 Inhibitor 99.66% Unkown
HY-N9503 Carvacryl acetate Activator 99.83% Unkown
HY-187618 GRC-17536 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trpa1 NCBI NCBI:8989