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Cat. No.: HY-187167

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TRPA1-IN-5

TRPA1-IN-5 is a TRPA1 inhibitor with inhibitory activity against TRPA1. TRPA1-IN-5 has pharmacokinetic and pharmacodynamic activities.

For research use only. We do not sell to patients.

CAS No.: 3136943-00-2
Formula: C₁₈H₁₇ClFN₅O₃
Molecular Weight:405.81

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TRPA1-IN-5 Chemical Structure

CAS No.: 3136943-00-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

TRPA1-IN-5 is a TRPA1 inhibitor with inhibitory activity against TRPA1. TRPA1-IN-5 has pharmacokinetic and pharmacodynamic activities^[1].

IC₅₀ & Target^[1]

hTRPA

2.93 nM (IC₅₀)

All TRP Channel Isoforms :

In Vitro

TRPA1-IN-5 (Compound 5) inhibits human TRPA1 in HEK293T cells stably expressing human TRPA1, with an IC₅₀ of 2.93 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	T_max	T_1/2	AUC_0-last	F
Rat^[1]	3 mg/kg	p.o.	1360 ng/mL	1.33 h	3.07 h	8200 ng·h/mL	77.3 %
Rat^[1]	1 mg/kg	i.v.	887 ng/mL	0.08 h	4.07 h	3536 ng·h/mL	/
Dog^[1]	1 mg/kg	i.v.	1014 ng/mL	0.03 h	12.7 h	6527 ng·h/mL	/

Chemical Information

CAS No. 3136943-00-2
Molecular Weight 405.81
Formula C₁₈H₁₇ClFN₅O₃
SMILES

CN1C(C(NCC2=NC([C@H]3C[C@H](C4=CC=C(Cl)C=C4)OC3)=NO2)=O)=C(F)N=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lou, J., et al. Compound as TRPA1 Inhibitor, Pharmaceutical Composition Thereof, and Use Thereof. WO2026139068 A1, 2 July 2026.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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TRPA1-IN-5

All TRP Channel Isoforms