TRPA1 - transient receptor potential cation channel subfamily A member 1 Gene

Also Known as FEPS; p120; FEPS1; ANKTM1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8989

About TRPA1

Cytogenetic location: 8q21.11 Genomic coordinates (GRCh38): 8:72,021,250-72,090,010 (from NCBI)

This gene has 6 transcripts (splice variants), 228 orthologues and is associated with 3 phenotypes. Biased expression in urinary bladder (RPKM 5.8), colon (RPKM 2.2) and 5 other tissues.

Summary

The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]

TRPA1 Products (1)

mRNA	Protein	Name
NM_007332.3	NP_015628.2	transient receptor potential cation channel subfamily A member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25855297	GOA
enables intracellularly gated calcium channel activity	IDA IDA: Inferred from direct assay	20547126	GOA
enables intracellularly gated calcium channel activity	IMP IMP: Inferred from mutant phenotype	25855297	GOA
enables temperature-gated cation channel activity	IDA IDA: Inferred from direct assay	20547126	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	20547126	GOA
involved in cellular response to hydrogen peroxide	IDA IDA: Inferred from direct assay	30990108	GOA
involved in intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	30990108	GOA
involved in protein homotetramerization	IDA IDA: Inferred from direct assay	25855297	GOA
involved in response to cold	IMP IMP: Inferred from mutant phenotype	20547126	GOA
involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	20547126	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	20547126	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRPA1 Protein Structure

Ank_2

Ank

Ank_2

Ion_trans

0
200
400
600
800
1000
1119 a.a.

Protein Preferred Names	Protein Names
transient receptor potential cation channel subfamily A member 1	ankyrin-like with transmembrane domains 1

TRPA1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRPA1	O75762	HUWE1	Homo sapiens	Q7Z6Z7	Crosslink	30021884
Intra	TRPA1	O75762	TRPA1	Homo sapiens	O75762	GMS	25855297
Intra	TRPA1	O75762	TRPA1	Homo sapiens	O75762	3D-EM	25855297

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Episodic Pain Syndrome, Familial, 1	FEPS1 Familial Episodic Pain Syndrome With Predominantly Upper Body Involvement Familial Episodic Pain Syndrome 1
Cramp-Fasciculation Syndrome	Cramp Fasciculation Syndrome Foley-Denny-Brown Syndrome
Dentin Sensitivity	Sensitive Dentin
Familial Episodic Pain Syndrome	Feps
Photokeratitis
Somatoform Disorder	Physiological Malfunction Arising From Mental Factor Psychosomatic Disorder Psychophysiologic Disorders
Lidocaine Allergy	Lidoderm Allergy Lignocaine Allergy Xylocaine Allergy
Irritable Bowel Syndrome	Irritable Colon Psychogenic Ibs Ibs - [Irritable Bowel Syndrome] Spastic Bowel Syndrome
Alcoholic Neuropathy	Alcoholic Polyneuropathy Alcohol-Related Polyneuropathy Alcohol-Induced Polyneuropathy Alcoholic Peripheral Neuropathy
Pain Agnosia	Analgesia
Interstitial Cystitis	Bladder Pain Syndrome Painful Bladder Syndrome Ulcerative Cystitis Ic/Bps Ic/Pbs Interstitial Cystitis/Bladder Pain Syndrome Interstitial Cystitis/Painful Bladder Syndrome Cystitis, Interstitial Chronic Interstitial Cystitis Pelvic Congestion Syndrome Trigonitis
Agnosia	Dyspraxia Primary Visual Agnosia Dyspraxia Syndrome Monomodal Visual Amnesia Visual Amnesia Agnosia, Primary Visual Apraxias Alexia
Complex Regional Pain Syndrome	Complex Regional Pain Syndromes Reflex Sympathetic Dystrophy Crps
Trigeminal Nerve Disease	Trigeminal Nerve Diseases Disorders Of 5th Cranial Nerve Disorders Of The Fifth Cranial Nerve
Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques	Olmsted Syndrome Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques Palmoplantar And Periorificial Keratoderma Olms
Episodic Pain Syndrome, Familial, 3	FEPS3 Familial Episodic Pain Syndrome With Predominantly Lower Limb Involvement Familial Episodic Pain Syndrome 3
Paine Syndrome	Pain Disorder Pain Microcephaly With Spastic Diplegia Pain Syndrome
Cough Variant Asthma
Episodic Pain Syndrome, Familial, 2	FEPS2 Familial Episodic Pain Syndrome 2
Hyperhidrosis, Gustatory	Frey Syndrome Gustatory Sweating Auriculotemporal Nerve Syndrome Gustatory Hyperhidrosis Frey'S Syndrome Sweating, Gustatory HYPRG Baillarger Syndrome Hyperhidrosis Gustatory Auriculotemporal Syndrome
Viral Laryngitis
Trigeminal Neuralgia	Tic Douloureux Trifacial Neuralgia Trifocal Neuralgia Neuralgia Of The Fifth Cranial Nerve Neuralgia Of 5th Cranial Nerve Infraorbital Neuralgia
Detrusor Sphincter Dyssynergia	Detrusor And Sphincter Dyssynergia
Spondyloepiphyseal Dysplasia, Maroteaux Type	Spondyloepiphyseal Dysplasia Maroteaux Type Pseudo-Morquio Syndrome Type 2 Sed, Maroteaux Type Brachyolmia Type 2 Pseudo-Morquio Syndrome, Type 2 Spondyloepiphyseal Dysplasia Of Maroteaux Brachyolmia Maroteaux Type SEDM Sed Maroteaux Type Dysplasia, Spondyloepiphyseal, Maroteaux Type
Paroxysmal Extreme Pain Disorder	PEPD Familial Rectal Pain Pexpd Submandibular, Ocular, And Rectal Pain With Flushing Pain, Submandibular, Ocular, And Rectal, With Flushing Rectal Pain, Familial Submandibular, Ocular And Rectal Pain With Flushing Familial Rectal Syndrome Frp Pain Disorder, Paroxysmal, Extreme
Autonomic Nervous System Disease	Autonomic Nervous System Dysfunction Autonomic Nervous System Disorders Autonomic Nervous System Disorder Autonomic Nervous System Diseases Abnormality Of The Autonomic Nervous System
Diabetic Neuropathy	Diabetic Neuropathies
Erythromelalgia	Primary Erythromelalgia Erythermalgia Primary Erythermalgia Mitchell Disease Familial Erythromelalgia
Neurodermatitis
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Lennox-Gastaut Syndrome	Lennox Syndrome Encephalopathy Of Childhood Epileptic Encephalopathy Lennox-Gastaut Type Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves Lgs
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-109061	Lazertinib	Activator	99.87%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-171846	LY3526318	Inhibitor	99.92%	Phase 2
HY-115877	GDC-0334	Antagonist	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (28)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107436	LE135	Activator	99.0%	Unkown
HY-W014421	AP-18	Inhibitor	99.61%	Unkown
HY-109061B	Lazertinib mesylate	Activator	99.85%	Unkown
HY-15065	Chembridge-5861528	Antagonist	99.12%	Unkown
HY-120689	PF-04745637	Antagonist	99.60%	Unkown
HY-N10319	Artepillin C	Agonist	99.07%	Unkown
HY-N7117	1,4-Cineole	Activator	95.0%	Unkown
HY-107535	AS1269574	Activator	99.84%	Unkown
HY-P1073	ProTx-I	Inhibitor	95.15%	Unkown
HY-153711	TRPA1-IN-2	Inhibitor	99.55%	Unkown
HY-172774	TRPV1 antagonist 10	Antagonist	98.54%	Unkown
HY-175980	TRPA1 agonist-3	Agonist	99.78%	Unkown
HY-15058	AMG2504	Antagonist	/	Unkown
HY-109061A	Lazertinib mesylate hydrate	Activator	/	Unkown
HY-179432	Cannabitwinol	Modulator	/	Unkown
HY-N7965	Methyl kakuol	Agonist	/	Unkown
HY-170652	ZQMT-10	Inhibitor	/	Unkown
HY-104062	AMG9678	Antagonist	/	Unkown
HY-162856	TRPV1-IN-2	Inhibitor	/	Unkown
HY-104061	AMG8788	Antagonist	/	Unkown
HY-127003	Neoambrosin	Agonist	/	Unkown
HY-122692	TRPV4/TRPA1-IN-1	Inhibitor	/	Unkown
HY-181762	Multitarget AD-IN-6	Inhibitor	/	Unkown
HY-113488	8,9-Epoxyeicosatrienoic acid		/	Unkown
HY-187167	TRPA1-IN-5	Inhibitor	/	Unkown
HY-159134	TRPA1-IN-3	Inhibitor	99.66%	Unkown
HY-N9503	Carvacryl acetate	Activator	99.83%	Unkown
HY-187618	GRC-17536	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TRPA1	MGD	MGI:3522699
Canis familiaris	TRPA1	VGNC	VGNC:47865
Felis catus	TRPA1	VGNC	VGNC:67587
Macaca mulatta	TRPA1	VGNC	VGNC:78429
Bos taurus	TRPA1	VGNC	VGNC:36380
Rattus norvegicus	TRPA1	RGD	RGD:1303284
Others	TRPA1	NCBI