AMY2A - amylase alpha 2A Gene

Also Known as PA; AMY2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 279

About AMY2A

Cytogenetic location: 1p21.1 Genomic coordinates (GRCh38): 1:103,616,651-103,625,780 (from NCBI)

This gene has 4 transcripts (splice variants), 194 orthologues and 7 paralogues. Restricted expression toward pancreas (RPKM 19140.7).

Summary

This gene encodes a member of the alpha-amylase family of proteins. Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and Polysaccharides, catalyzing the first step in digestion of dietary starch and glycogen. This gene and several family members are present in a gene cluster on chromosome 1. This gene encodes an amylase isoenzyme produced by the pancreas. [provided by RefSeq, Jan 2015]

AMY2A Products (1)

mRNA Protein Name
NM_000699.4 NP_000690.1 pancreatic alpha-amylase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alpha-amylase activity IDA
IDA: Inferred from direct assay
10769135 GOA
enables calcium ion binding IDA
IDA: Inferred from direct assay
10769135 GOA
enables chloride ion binding IDA
IDA: Inferred from direct assay
10769135 GOA
Biological Process GO Annotation Evidence References Source
involved in carbohydrate catabolic process IDA
IDA: Inferred from direct assay
10769135 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
10769135 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AMY2A Protein Structure

Alpha-amylase

Alpha-amylase: Alpha amylase, catalytic domain (46 - 345)

Alpha-amylase_C

Alpha-amylase_C: Alpha amylase, C-terminal all-beta domain (425 - 505)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 511 a.a.
Protein Preferred Names Protein Names

pancreatic alpha-amylase

  • 1,4-alpha-D-glucan glucanohydrolase

Recombinant AMY2A Proteins

Cat. No. Product Name Accession Purity
HY-P76722 AMY2A Protein, Human (HEK293, His) P04746 (Q16-L511) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Pancreatitis

  • Mumps Pancreatitis
Ichthyosis, Congenital, Autosomal Recessive 10

  • Autosomal Recessive Congenital Ichthyosis 10

  • ARCI10

  • Ichthyosis, Congenital, Autosomal Recessive, Type 10
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00673 AMY2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18266 Amy2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown