Desi1 - desumoylating isopeptidase 1 Gene

Mus musculus

Also known as DeSI-1; Pppde2; Fam152b; D15Wsu75e

Gene ID: 28075 | Gene type: protein coding

About Desi1

Summary

Enables SUMO-specific isopeptidase activity and identical protein binding activity. Involved in protein desumoylation. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Is expressed in extraembryonic component. Orthologous to human DESI1 (desumoylating isopeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]

Desi1 Products(2)

mRNA	Protein	Name
NM_001356541.2	NP_001343470.1	desumoylating isopeptidase 1 isoform 2
NM_134095.4	NP_598856.1	desumoylating isopeptidase 1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables deSUMOylase activity	IDA IDA: Inferred from direct assay	22370726	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	22370726	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22370726	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein desumoylation	IDA IDA: Inferred from direct assay	22370726	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

desumoylating isopeptidase 1

PPPDE peptidase domain containing 2	PPPDE peptidase domain-containing protein 2
family with sequence similarity 152, member B

Desi1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Desi1	Q9CQT7	Rplp0	Mus musculus	P14869	Y2H Pooling	22370726
Intra	Desi1	Q9CQT7	Uba5	Mus musculus	Q8VE47	Y2H Pooling	22370726
Intra	Desi1	Q9CQT7	Slbp	Mus musculus	P97440	Y2H Pooling	22370726
Intra	Desi1	Q9CQT7	B2m	Mus musculus	P01887	Y2H Pooling	22370726
Intra	Desi1	Q9CQT7	Ppp2r5a	Mus musculus	Q6PD03	Y2H Pooling	22370726
Intra	Desi1	Q9CQT7	SUMO3	Homo sapiens	P55854	Protease Assay	22370726
Intra	Desi1	Q9CQT7	Desi1	Mus musculus	Q9CQT7	Y2H Pooling	22370726
Intra	Desi1	Q9CQT7	Pcna	Mus musculus	P17918	Y2H Pooling	22370726
Intra	Desi1	Q9CQT7	Desi1	Mus musculus	Q9CQT7	GMS	22370726
Intra	Desi1	Q9CQT7	SUMO2	Homo sapiens	P61956	Protease Assay	22370726
Intra	Desi1	Q9CQT7	Rack1	Mus musculus	P68040	Y2H Pooling	22370726
Intra	Desi1	Q9CQT7	Zbtb46	Mus musculus	Q8BID6	Anti Tag CoIP	22370726
Intra	Desi1	Q9CQT7	Rps4x	Mus musculus	Q545X8	Y2H Pooling	22370726
Intra	Desi1	Q9CQT7	Zbtb46	Mus musculus	Q8BID6	Y2H Pooling	22370726
Intra	Desi1	Q9CQT7	Desi1	Mus musculus	Q9CQT7	Anti Tag CoIP	22370726
Intra	Desi1	Q9CQT7	Phb1	Mus musculus	P67778	Y2H Pooling	22370726

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03704	DESI1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03705	DESI2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Desi1	NCBI	NCBI:27351

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