Desi1 - desumoylating isopeptidase 1 Gene

Also Known as DeSI-1; Pppde2; Fam152b; D15Wsu75e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 28075

Summary

Enables SUMO-specific isopeptidase activity and identical protein binding activity. Involved in protein desumoylation. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Is expressed in extraembryonic component. Orthologous to human DESI1 (desumoylating isopeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]

Desi1 Products (2)

mRNA Protein Name
NM_001356541.2 NP_001343470.1 desumoylating isopeptidase 1 isoform 2
NM_134095.4 NP_598856.1 desumoylating isopeptidase 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables deSUMOylase activity IDA
IDA: Inferred from direct assay
22370726 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
22370726 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22370726 MGI
Biological Process GO Annotation Evidence References Source
involved in protein desumoylation IDA
IDA: Inferred from direct assay
22370726 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

desumoylating isopeptidase 1

  • PPPDE peptidase domain containing 2

  • PPPDE peptidase domain-containing protein 2

  • family with sequence similarity 152, member B

Desi1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Desi1 Q9CQT7 Rplp0 Mus musculus P14869
Y2H Pooling
22370726
Intra
Desi1 Q9CQT7 Uba5 Mus musculus Q8VE47
Y2H Pooling
22370726
Intra
Desi1 Q9CQT7 Slbp Mus musculus P97440
Y2H Pooling
22370726
Intra
Desi1 Q9CQT7 B2m Mus musculus P01887
Y2H Pooling
22370726
Intra
Desi1 Q9CQT7 Ppp2r5a Mus musculus Q6PD03
Y2H Pooling
22370726
Intra
Desi1 Q9CQT7 SUMO3 Homo sapiens P55854
Protease Assay
22370726
Intra
Desi1 Q9CQT7 Desi1 Mus musculus Q9CQT7
Y2H Pooling
22370726
Intra
Desi1 Q9CQT7 Pcna Mus musculus P17918
Y2H Pooling
22370726
Intra
Desi1 Q9CQT7 Desi1 Mus musculus Q9CQT7
GMS
22370726
Intra
Desi1 Q9CQT7 SUMO2 Homo sapiens P61956
Protease Assay
22370726
Intra
Desi1 Q9CQT7 Rack1 Mus musculus P68040
Y2H Pooling
22370726
Intra
Desi1 Q9CQT7 Zbtb46 Mus musculus Q8BID6
Anti Tag CoIP
22370726
Intra
Desi1 Q9CQT7 Rps4x Mus musculus Q545X8
Y2H Pooling
22370726
Intra
Desi1 Q9CQT7 Zbtb46 Mus musculus Q8BID6
Y2H Pooling
22370726
Intra
Desi1 Q9CQT7 Desi1 Mus musculus Q9CQT7
Anti Tag CoIP
22370726
Intra
Desi1 Q9CQT7 Phb1 Mus musculus P67778
Y2H Pooling
22370726
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03704 DESI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03705 DESI2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Desi1 NCBI NCBI:27351