GPD1 - glycerol-3-phosphate dehydrogenase 1 Gene

Also Known as GPD-C; HTGTI; GPDH-C

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2819

About GPD1

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:50,104,008-50,111,313 (from NCBI)

This gene has 7 transcripts (splice variants), 275 orthologues, 1 paralogue and is associated with 2 phenotypes. Biased expression in fat (RPKM 448.5), kidney (RPKM 83.8) and 3 other tissues.

Summary

This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

GPD1 Products (2)

mRNA Protein Name
NM_001257199.2 NP_001244128.1 glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform 2
NM_005276.4 NP_005267.2 glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPD1 Protein Structure

NAD_Gly3P_dh_N

NAD_Gly3P_dh_N: NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus (5 - 172)

NAD_Gly3P_dh_C

NAD_Gly3P_dh_C: NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus (193 - 342)

  • 0
  • 100
  • 200
  • 300
  • 349 a.a.
Protein Preferred Names Protein Names

glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

  • epididymis secretory sperm binding protein

GPD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GPD1 P21695 FAM25C Homo sapiens B3EWG5
Y2H Array
32296183
Intra
GPD1 P21695 FAM25C Homo sapiens B3EWG5
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GPD1 Proteins

Cat. No. Product Name Accession Purity
HY-P70320 GPD1 Protein, Human (HEK293, His) P21695-1 (M1-M349) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Hypertriglyceridemia, Transient Infantile

  • Transient Infantile Hypertriglyceridemia And Hepatosteatosis

  • HTGTI

  • Transient Infantile Hypertriglyceridemia And Fatty Liver

  • Hypertriglyceridemia
Brugada Syndrome 2

  • BRGDA2

  • Brugada Syndrome, Type 2
Brugada Syndrome

  • Sudden Unexpected Nocturnal Death Syndrome

  • Sudden Unexplained Nocturnal Death Syndrome

  • Bangungut

  • Brugada Type Idiopathic Ventricular Fibrillation

  • Pokkuri Death Syndrome

  • Sunds

  • Idiopathic Ventricular Fibrillation, Brugada Type

  • Sudden Unexplained Death

  • Dream Disease

  • Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome

  • Sudden Unexplained Death Syndrome

  • Suds

  • Sunds - [Sudden Unexplained Nocturnal Death Syndrome]
Brugada Syndrome 1

  • BRGDA1

  • Sudden Unexplained Nocturnal Death Syndrome

  • Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome

  • Sunds

  • Brugada Syndrome, Type 1

  • Brugada Syndrome
Cryptococcal Meningitis

  • Meningitis, Cryptococcal

  • Meningitis Cryptococcal
Cryptococcosis

  • Cryptococcus Neoformans Infection

  • Torulosis

  • Busse-Buschke'S Disease

  • Cryptococcal Infection

  • European Cryptococcosis

  • Torula

  • Infection By Cryptococcus Neoformans

  • Cryptococcosis Infection

  • European Blastomycosis

  • European Blastomycotic Infection

  • European Blastomycoses Infection

  • Torula Histolytica Infection
Fungal Meningitis

  • Meningitis, Fungal

  • Mycotic Meningitis
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Mitochondrial Complex I Deficiency, Nuclear Type 1

  • Mitochondrial Complex I Deficiency

  • Nadh:Q(1) Oxidoreductase Deficiency

  • MC1DN1

  • Nadh-Coenzyme Q Reductase Deficiency

  • Isolated Mitochondrial Respiratory Chain Complex I Deficiency

  • Isolated Nadh-Coenzyme Q Reductase Deficiency

  • Isolated Nadh-Coq Reductase Deficiency

  • Isolated Nadh-Ubiquinone Reductase Deficiency

  • Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of

  • Nuclear Type Mitochondrial Complex I Deficiency 1

  • Isolated Complex I Deficiency

  • Complex 1 Mitochondrial Respiratory Chain Deficiency

  • Nadh Coenzyme Q Reductase Deficiency

  • Complex I Mitochondrial Respiratory Chain Deficiency

  • Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I

  • Nadh:Ubiquinone Oxidoreductase Deficiency

  • Complex I, Mitochondrial Respiratory Chain, Deficiency Of
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Zellweger Syndrome

  • Cerebrohepatorenal Syndrome

  • Zellweger Leukodystrophy

  • Zs

  • Congenital Iron Overload

  • Chr

  • Zws

  • Severe Pbd-Zsd

  • Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05633 GPD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05634 GPD1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17126 H6pd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18615 Gpd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21586 Gpd1l Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25101 Gpd1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28104 Gpd1l Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GPD1 MGD MGI:95679
Felis catus GPD1 VGNC VGNC:67407
Canis familiaris GPD1 VGNC VGNC:41376
Rattus norvegicus GPD1 RGD RGD:621381
Bos taurus GPD1 VGNC VGNC:29529
Others GPD1 NCBI