ALKAL2 - ALK and LTK ligand 2 Gene

Also Known as AUGA; FAM150B; PRO1097; RGPG542

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 285016

About ALKAL2

Cytogenetic location: 2p25.3 Genomic coordinates (GRCh38): 2:279,558-288,091 (from NCBI)

This gene has 8 transcripts (splice variants) and 125 orthologues. Biased expression in adrenal (RPKM 46.6), ovary (RPKM 14.2) and 6 other tissues.

Summary

Enables receptor signaling protein tyrosine kinase activator activity and receptor tyrosine kinase binding activity. Involved in positive regulation of ERK1 and ERK2 cascade; positive regulation of ERK5 cascade; and positive regulation of neuron projection development. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

ALKAL2 Products (1)

mRNA Protein Name
NM_001002919.3 NP_001002919.2 ALK and LTK ligand 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytokine activity IDA
IDA: Inferred from direct assay
30061385 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
26418745 GOA
enables receptor signaling protein tyrosine kinase activator activity IDA
IDA: Inferred from direct assay
26418745 GOA
enables receptor tyrosine kinase binding IDA
IDA: Inferred from direct assay
26418745 GOA
enables transmembrane receptor protein tyrosine kinase activator activity IDA
IDA: Inferred from direct assay
30061385 GOA
Biological Process GO Annotation Evidence References Source
involved in cell surface receptor protein tyrosine kinase signaling pathway IDA
IDA: Inferred from direct assay
30061385 GOA
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
26418745 GOA
involved in positive regulation of ERK5 cascade IDA
IDA: Inferred from direct assay
26418745 GOA
involved in positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
26418745 GOA
Cellular Component GO Annotation Evidence References Source
is active in extracellular region IDA
IDA: Inferred from direct assay
30061385 GOA
is active in extracellular space IDA
IDA: Inferred from direct assay
30061385 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALKAL2 Protein Structure

FAM150

FAM150: FAM150 family (33 - 149)

  • 0
  • 100
  • 152 a.a.
Protein Preferred Names Protein Names

ALK and LTK ligand 2

  • AUG-alpha

Related Diseases

Diseases Alias
Meier-Gorlin Syndrome 4

  • MGORS4

  • Meier-Gorlin Syndrome, Type 4
Inflammatory Myofibroblastic Tumor

  • Inflammatory Fibrosarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00602 ALKAL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ALKAL2 MGD MGI:3697448
Macaca mulatta ALKAL2 VGNC VGNC:82102
Rattus norvegicus ALKAL2 RGD RGD:1587117
Bos taurus ALKAL2 VGNC VGNC:106637