TCAF2 - TRPM8 channel associated factor 2 Gene

Also Known as GATD9; GATD9B; FAM115C; FAM139A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 285966

About TCAF2

Cytogenetic location: 7q35 Genomic coordinates (GRCh38): 7:143,620,974-143,730,410 (from NCBI)

This gene has 8 transcripts (splice variants), 312 orthologues and 2 paralogues. Ubiquitous expression in esophagus (RPKM 2.3), placenta (RPKM 2.1) and 25 other tissues.

Summary

Enables transmembrane transporter binding activity. Involved in negative regulation of anion channel activity; positive regulation of cell migration; and positive regulation of protein targeting to membrane. Located in cell junction and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TCAF2 Products (7)

mRNA	Protein	Name
NM_001130026.3	NP_001123498.2	TRPM8 channel-associated factor 2 isoform B
NM_001363538.2	NP_001350467.1	TRPM8 channel-associated factor 2 isoform C
NM_001365427.2	NP_001352356.1	TRPM8 channel-associated factor 2 isoform D
NM_001365428.1	NP_001352357.1	TRPM8 channel-associated factor 2 isoform E
NM_001365429.1	NP_001352358.1	TRPM8 channel-associated factor 2 isoform F
NM_001365430.1	NP_001352359.1	TRPM8 channel-associated factor 2 isoform F
NM_173678.3	NP_775949.2	TRPM8 channel-associated factor 2 isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables transmembrane transporter binding	IDA IDA: Inferred from direct assay	25559186	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	25559186	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of anion channel activity	IDA IDA: Inferred from direct assay	25559186	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	25559186	GOA
involved in positive regulation of protein targeting to membrane	IMP IMP: Inferred from mutant phenotype	25559186	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	25559186	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCAF2 Protein Structure

Peptidase_M60

0
200
400
600
800
919 a.a.

Protein Preferred Names	Protein Names
TRPM8 channel-associated factor 2	TRP channel-associated factor 2

Related Diseases

Diseases	Alias
Chromosome 13q14 Deletion Syndrome	Chromosome 13q Deletion Syndrome Deletion 13q14 Chromosome 13q Deletion 13q Deletion 13q Monosomy Deletion 13q Monosomy 13q Monosomy 13q14 Del(13)(Q14)

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14289	TCAF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TCAF2	RGD	RGD:6487302
Mus musculus	TCAF2	MGD	MGI:2385258