Slc22a2 - solute carrier family 22 member 2 Gene

Also Known as OCT2; OCT2r; rOCT2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29503

Summary

Enables several functions, including organic cation transmembrane transporter activity; toxin transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in several processes, including cation transport; quaternary ammonium group transport; and toxin transport. Acts upstream of or within positive regulation of gene expression. Located in apical plasma membrane and basolateral plasma membrane. Is integral component of plasma membrane. Used to study acute kidney failure. Biomarker of cholestasis (multiple); hyperuricemia; and kidney failure (multiple). Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to human SLC22A2 (solute carrier family 22 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc22a2 Products (1)

mRNA Protein Name
NM_031584.2 NP_113772.1 solute carrier family 22 member 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables acetylcholine transmembrane transporter activity IDA
IDA: Inferred from direct assay
15817714 RGD
enables choline transmembrane transporter activity IDA
IDA: Inferred from direct assay
11553644 RGD
enables monoamine transmembrane transporter activity IDA
IDA: Inferred from direct assay
9812985 RGD
enables neurotransmitter transmembrane transporter activity IDA
IDA: Inferred from direct assay
9812985 RGD
enables organic cation transmembrane transporter activity IDA
IDA: Inferred from direct assay
10889205 RGD
enables quaternary ammonium group transmembrane transporter activity IDA
IDA: Inferred from direct assay
9808712 RGD
enables steroid binding IDA
IDA: Inferred from direct assay
14573752 RGD
enables toxin transmembrane transporter activity IDA
IDA: Inferred from direct assay
20924140 RGD
enables toxin transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
20477935 RGD
enables xenobiotic transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
20477935 RGD
Biological Process GO Annotation Evidence References Source
involved in acetylcholine transport IDA
IDA: Inferred from direct assay
15817714 RGD
acts upstream of activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
30120945 RGD
involved in cellular detoxification IDA
IDA: Inferred from direct assay
20924140 RGD
involved in cellular detoxification IMP
IMP: Inferred from mutant phenotype
20477935 RGD
involved in dopamine transport IDA
IDA: Inferred from direct assay
9812985 RGD
involved in epinephrine transport IDA
IDA: Inferred from direct assay
9812985 RGD
involved in histamine transport IDA
IDA: Inferred from direct assay
16581093 RGD
involved in norepinephrine transport IDA
IDA: Inferred from direct assay
9812985 RGD
involved in organic cation transport IDA
IDA: Inferred from direct assay
19211691 RGD
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
30120945 RGD
involved in quaternary ammonium group transport IDA
IDA: Inferred from direct assay
9808712 RGD
involved in serotonin transport IDA
IDA: Inferred from direct assay
9812985 RGD
involved in xenobiotic transport IDA
IDA: Inferred from direct assay
20924140 RGD
involved in xenobiotic transport IMP
IMP: Inferred from mutant phenotype
20477935 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
15817714 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
9808712 RGD
is active in cholinergic synapse IDA
IDA: Inferred from direct assay
23958595 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
12176030 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
23958595 RGD
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
23958595 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

solute carrier family 22 member 2

  • organic cation transporter 2

  • solute carrier family 22 (organic cation transporter), member 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13072 SLC22A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc22a2 NCBI NCBI:6582