Slc22a2 - solute carrier family 22 member 2 Gene

Rattus norvegicus

Also known as OCT2; OCT2r; rOCT2

Gene ID: 29503 | Gene type: protein coding

About Slc22a2

Summary

Enables several functions, including organic cation transmembrane transporter activity; toxin transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in several processes, including cation transport; quaternary ammonium group transport; and toxin transport. Acts upstream of or within positive regulation of gene expression. Located in apical plasma membrane and basolateral plasma membrane. Is integral component of plasma membrane. Used to study acute kidney failure. Biomarker of cholestasis (multiple); hyperuricemia; and kidney failure (multiple). Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to human SLC22A2 (solute carrier family 22 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc22a2 Products(1)

mRNA	Protein	Name
NM_031584.2	NP_113772.1	solute carrier family 22 member 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables acetylcholine transmembrane transporter activity	IDA IDA: Inferred from direct assay	15817714	RGD
enables choline transmembrane transporter activity	IDA IDA: Inferred from direct assay	11553644	RGD
enables monoamine transmembrane transporter activity	IDA IDA: Inferred from direct assay	9812985	RGD
enables neurotransmitter transmembrane transporter activity	IDA IDA: Inferred from direct assay	9812985	RGD
enables organic cation transmembrane transporter activity	IDA IDA: Inferred from direct assay	10889205	RGD
enables quaternary ammonium group transmembrane transporter activity	IDA IDA: Inferred from direct assay	9808712	RGD
enables steroid binding	IDA IDA: Inferred from direct assay	14573752	RGD
enables toxin transmembrane transporter activity	IDA IDA: Inferred from direct assay	20924140	RGD
enables toxin transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	20477935	RGD
enables xenobiotic transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	20477935	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in acetylcholine transport	IDA IDA: Inferred from direct assay	15817714	RGD
acts upstream of activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	30120945	RGD
involved in cellular detoxification	IDA IDA: Inferred from direct assay	20924140	RGD
involved in cellular detoxification	IMP IMP: Inferred from mutant phenotype	20477935	RGD
involved in dopamine transport	IDA IDA: Inferred from direct assay	9812985	RGD
involved in epinephrine transport	IDA IDA: Inferred from direct assay	9812985	RGD
involved in histamine transport	IDA IDA: Inferred from direct assay	16581093	RGD
involved in norepinephrine transport	IDA IDA: Inferred from direct assay	9812985	RGD
involved in organic cation transport	IDA IDA: Inferred from direct assay	19211691	RGD
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	30120945	RGD
involved in quaternary ammonium group transport	IDA IDA: Inferred from direct assay	9808712	RGD
involved in serotonin transport	IDA IDA: Inferred from direct assay	9812985	RGD
involved in xenobiotic transport	IDA IDA: Inferred from direct assay	20924140	RGD
involved in xenobiotic transport	IMP IMP: Inferred from mutant phenotype	20477935	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15817714	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	9808712	RGD
is active in cholinergic synapse	IDA IDA: Inferred from direct assay	23958595	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	12176030	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	23958595	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	23958595	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

solute carrier family 22 member 2

organic cation transporter 2

solute carrier family 22 (organic cation transporter), member 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13072	SLC22A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc22a2	NCBI	NCBI:6582

Name
Email *

	Sorry, but the email address you supplied was invalid.