Ptprn2 - protein tyrosine phosphatase, receptor type N2 Gene

Also Known as PTPNE6; R-PTP-N2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29714

Summary

Predicted to enable protein tyrosine Phosphatase activity. Involved in negative regulation of GTPase activity. Located in endoplasmic reticulum lumen; secretory granule; and terminal bouton. Is integral component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in prediabetes syndrome and type 1 diabetes mellitus. Orthologous to human PTPRN2 (protein tyrosine Phosphatase receptor type N2). [provided by Alliance of Genome Resources, Apr 2022]

Ptprn2 Products (1)

mRNA Protein Name
NM_031600.2 NP_113788.1 receptor-type tyrosine-protein phosphatase N2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16413169 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of GTPase activity IDA
IDA: Inferred from direct assay
16413169 RGD
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum lumen IDA
IDA: Inferred from direct assay
8663434 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
27630542 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
8663434 RGD
is active in synaptic vesicle membrane EXP
EXP: Inferred from Experiment
23622064 RGD
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
23622064 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
9714834 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase N2

  • PTP NE-6

  • phogrin

  • protein tyrosine phosphatase receptor-type N polypeptide 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11445 PTPRN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptprn2 NCBI NCBI:5799