2. Gene
  3. Ptprn2 - protein tyrosine phosphatase, receptor type N2 Gene

Ptprn2 - protein tyrosine phosphatase, receptor type N2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as PTPNE6; R-PTP-N2

Gene ID: 29714 | Gene type: protein coding

About Ptprn2

Summary

Predicted to enable protein tyrosine Phosphatase activity. Involved in negative regulation of GTPase activity. Located in endoplasmic reticulum lumen; secretory granule; and terminal bouton. Is integral component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in prediabetes syndrome and type 1 diabetes mellitus. Orthologous to human PTPRN2 (protein tyrosine Phosphatase receptor type N2). [provided by Alliance of Genome Resources, Apr 2022]

Ptprn2 Products(1)

mRNA Protein Name
NM_031600.2 NP_113788.1 receptor-type tyrosine-protein phosphatase N2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16413169 RGD
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of GTPase activity IDA
IDA: Inferred from direct assay
16413169 RGD
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum lumen IDA
IDA: Inferred from direct assay
8663434 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
27630542 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
8663434 RGD
is active in synaptic vesicle membrane EXP
EXP: Inferred from Experiment
23622064 RGD
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
23622064 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
9714834 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase N2

PTP NE-6

phogrin

protein tyrosine phosphatase receptor-type N polypeptide 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11445 PTPRN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptprn2 NCBI NCBI:5799