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PTPRN2 - protein tyrosine phosphatase receptor type N2 Gene

Also Known as IAR; ICAAR; PTPRP; IA-2beta; R-PTP-N2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5799

About PTPRN2

Cytogenetic location: 7q36.3 Genomic coordinates (GRCh38): 7:157,539,056-158,587,823 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 200 orthologues and 35 paralogues. Broad expression in brain (RPKM 7.2), stomach (RPKM 4.9) and 18 other tissues.

Summary

This gene encodes a protein with sequence similarity to receptor-like Protein tyrosine phosphatases. However, tyrosine Phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol Phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of Insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

PTPRN2 Products (5)

mRNA	Protein	Name
NM_001308267.2	NP_001295196.1	receptor-type tyrosine-protein phosphatase N2 isoform 4 precursor
NM_001308268.2	NP_001295197.1	receptor-type tyrosine-protein phosphatase N2 isoform 5
NM_002847.5	NP_002838.2	receptor-type tyrosine-protein phosphatase N2 isoform 1 precursor
NM_130842.4	NP_570857.2	receptor-type tyrosine-protein phosphatase N2 isoform 2 precursor
NM_130843.4	NP_570858.2	receptor-type tyrosine-protein phosphatase N2 isoform 3 precursor

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	References	Source
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPRN2 Protein Structure

RESP18

Receptor_IA-2

Y_phosphatase

0
200
400
600
800
1015 a.a.

Protein Preferred Names	Protein Names
receptor-type tyrosine-protein phosphatase N2	IAR/receptor-like protein-tyrosine phosphatase

Related Diseases

Diseases	Alias
Insulinoma	Islet Cell Adenoma Insulin-Producing Tumor Of Islet Cells Adenoma Islet Cell Islet Cell Tumor Experimental Organism Islet Cell Adenoma Neoplasm
Diabetes Mellitus	Diabetes
Type 1 Diabetes Mellitus 5	Diabetes Mellitus, Insulin-Dependent, 5 Latent Autoimmune Diabetes In Adults IDDM5 Insulin-Dependent Diabetes Mellitus 5 T1D5 Lada Type 1.5 Diabetes Diabetes Mellitus, Insulin-Dependent, Type 5
Bleeding Disorder, Platelet-Type, 17	Platelet-Type Bleeding Disorder 17 BDPLT17 Thrombasthenia-Thrombocytopenia, Hereditary Hereditary Thrombasthenia-Thrombocytopenia Autosomal Dominant Macrothrombocytopenia Gfi1b-Related Autosomal Dominant Platelet Disorder Gfi1b-Related Bleeding Disorder, Platelet Type 17
Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia, And Hydranencephaly	MARCH Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia And Hydranencephaly Multinucleated Neurons-Anhydramnios-Renal Dysplasia-Cerebellar Hypoplasia-Hydranencephaly Syndrome Hydranencephaly With Renal Aplasia-Dysplasia March Syndrome
Pancreatic Cystadenoma	Cystadenoma Of Pancreas
Type 1 Diabetes Mellitus 2	Diabetes Mellitus, Noninsulin-Dependent, 1 Diabetes Mellitus, Insulin-Dependent, 2 IDDM2 Insulin-Dependent Diabetes Mellitus 2 NIDDM1 Diabetes Mellitus, Noninsulin-Dependent 1 T1D2 Type 2 Diabetes Mellitus 1 T2D1 Noninsulin-Dependent Diabetes Mellitus 1 Diabetes Mellitus, Non-Insulin-Dependent, 1 Type 2 Diabetes Mellitus 1, Susceptibility To Diabetes Mellitus, Insulin-Dependent, Type 2 Diabetes Mellitus, Non-Insulin-Dependent
Type 1 Diabetes Mellitus	Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus Type 1 IDDM Type 1 Diabetes Insulin-Dependent Diabetes Mellitus T1D Juvenile-Onset Diabetes Jod Diabetes Mellitus, Type 1 Diabetes Mellitus, Insulin-Dependent-1 Type I Diabetes Mellitus Autoimmune Diabetes Juvenile Diabetes Juvenile-Onset Diabetes Mellitus Diabetes, Insulin Dependent Insulin-Dependent Diabetes Mellitus-1 Diabetes Mellitus Insulin-Dependent Diabetes Autoimmune Diabetes Mellitus, Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 1, Susceptibility To Diabetes Type 1 Type I Diabetes Diabetes, Autoimmune T1dm - [Type 1 Diabetes Mellitus] Iddm - [Insulin Dependent Diabetes Mellitus] Type 1 Iddm Juvenile Diabetes Mellitus Without Compications Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications Juvenile-Onset Diabetes Mellitus Without Compications Ketosis-Prone Diabetes Mellitus Without Compications Juvenile-Onset-Type Diabetes Mellitus Without Compications
Duane Retraction Syndrome	Stilling-Turk-Duane Syndrome Duane'S Syndrome Duane Syndrome Isolated Duane Retraction Syndrome Co-Contractive Retraction Syndrome Duane Anomaly, Isolated Ocular Retraction Syndrome Drs Durs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11445	PTPRN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PTPRN2	VGNC	VGNC:45194
Mus musculus	PTPRN2	MGD	MGI:107418
Felis catus	PTPRN2	VGNC	VGNC:80666
Macaca mulatta	PTPRN2	VGNC	VGNC:84752
Bos taurus	PTPRN2	VGNC	VGNC:106884
Rattus norvegicus	PTPRN2	RGD	RGD:61904
Others	PTPRN2	NCBI