2. Gene
  3. SLC8A1 - Slc8a1 solute carrier family 8 member A1 Gene

SLC8A1 - Slc8a1 solute carrier family 8 member A1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Ncx; Ncx1

Gene ID: 29715 | Gene type: protein coding

About SLC8A1

Summary

Enables calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration; calcium:sodium antiporter activity; and ion antiporter activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including metal ion transport; regulation of heart contraction; and response to purine-containing compound. Located in several cellular components, including T-tubule; Z disc; and dendrite. Is integral component of postsynaptic membrane. Used to study brain ischemia. Biomarker of brain ischemia; congestive heart failure; hypertension; and status epilepticus. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SLC8A1 (solute carrier family 8 member A1). [provided by Alliance of Genome Resources, Apr 2022]

SLC8A1 Products(9)

mRNA Protein Name
NM_001270772.2 NP_001257701.1 sodium/calcium exchanger 1 isoform 2 precursor
NM_001270773.2 NP_001257702.1 sodium/calcium exchanger 1 isoform 3 precursor
NM_001270774.2 NP_001257703.1 sodium/calcium exchanger 1 isoform 4 precursor
NM_001270775.2 NP_001257704.1 sodium/calcium exchanger 1 isoform 5 precursor
NM_001270776.2 NP_001257705.1 sodium/calcium exchanger 1 isoform 6 precursor
NM_001270777.2 NP_001257706.1 sodium/calcium exchanger 1 isoform 7 precursor
NM_001270778.2 NP_001257707.1 sodium/calcium exchanger 1 isoform 8 precursor
NM_001270779.2 NP_001257708.1 sodium/calcium exchanger 1 isoform 9 precursor
NM_019268.4 NP_062141.3 sodium/calcium exchanger 1 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium:sodium antiporter activity IDA
IDA: Inferred from direct assay
7642578 RGD
enables calcium:sodium antiporter activity IMP
IMP: Inferred from mutant phenotype
15774479 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
14593108 RGD
Biological Process GO Annotation Evidence Reference Source
involved in calcium ion export IDA
IDA: Inferred from direct assay
19481548 RGD
involved in calcium ion import IDA
IDA: Inferred from direct assay
11916852 RGD
involved in calcium ion transmembrane transport IDA
IDA: Inferred from direct assay
11342562 RGD
involved in calcium ion transmembrane transport IGI
IGI: Inferred from genetic interaction
23628073 RGD
involved in calcium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
17215351 RGD
involved in calcium ion transport into cytosol IDA
IDA: Inferred from direct assay
9486131 RGD
involved in cell communication by electrical coupling involved in cardiac conduction IDA
IDA: Inferred from direct assay
21779914 RGD
involved in cellular response to cAMP IDA
IDA: Inferred from direct assay
9486131 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
17394575 RGD
involved in cellular response to reactive oxygen species IDA
IDA: Inferred from direct assay
19481548 RGD
acts upstream of or within intracellular calcium ion homeostasis IGI
IGI: Inferred from genetic interaction
23628073 RGD
involved in intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
12234816 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
16679322 RGD
involved in positive regulation of fibroblast migration IMP
IMP: Inferred from mutant phenotype
19770194 RGD
involved in regulation of calcium ion transport IMP
IMP: Inferred from mutant phenotype
15774479 RGD
involved in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IDA
IDA: Inferred from direct assay
21779914 RGD
involved in regulation of sodium ion transport IMP
IMP: Inferred from mutant phenotype
15774479 RGD
involved in response to ATP IDA
IDA: Inferred from direct assay
17466270 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
17446486 RGD
involved in response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
17446483 RGD
involved in response to hypoxia IDA
IDA: Inferred from direct assay
17267548 RGD
involved in response to immobilization stress IEP
IEP: Inferred from expression pattern
17394575 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
17612656 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16343576 RGD
involved in sodium ion export across plasma membrane IDA
IDA: Inferred from direct assay
11916852 RGD
involved in sodium ion import across plasma membrane IDA
IDA: Inferred from direct assay
11916852 RGD
involved in sodium ion transport IDA
IDA: Inferred from direct assay
9486131 RGD
involved in telencephalon development IEP
IEP: Inferred from expression pattern
12502534 RGD
Cellular Component GO Annotation Evidence Reference Source
located in T-tubule IDA
IDA: Inferred from direct assay
1514597 RGD
located in Z disc IDA
IDA: Inferred from direct assay
1514597 RGD
located in axon IDA
IDA: Inferred from direct assay
23628073 RGD
located in cell projection IDA
IDA: Inferred from direct assay
16914199 RGD
located in dendrite IDA
IDA: Inferred from direct assay
23628073 RGD
located in dendritic shaft IDA
IDA: Inferred from direct assay
17215351 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
16914199 RGD
located in intercalated disc IDA
IDA: Inferred from direct assay
1514597 RGD
located in microtubule IDA
IDA: Inferred from direct assay
16914199 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
23628073 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
16914199 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
1514597 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium/calcium exchanger 1

Na(+)/Ca(2+)-exchange protein 1

Na-Ca exchanger

solute carrier family 8 (sodium/calcium exchanger), member 1

solute carrier family 8 member 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13337 SLC8A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13340 SLC8B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20598 Slc8b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27106 Slc8b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens SLC8A1 NCBI NCBI:6546