GUK1 - guanylate kinase 1 Gene

Also Known as GMK

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2987

About GUK1

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:228,140,084-228,148,955 (from NCBI)

This gene has 39 transcripts (splice variants) and 306 orthologues. Ubiquitous expression in bone marrow (RPKM 25.0), adrenal (RPKM 18.8) and 25 other tissues.

Summary

The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for Cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GUK1 Products (5)

mRNA	Protein	Name
NM_000858.7	NP_000849.1	guanylate kinase isoform b
NM_001159390.2	NP_001152862.1	guanylate kinase isoform a
NM_001159391.3	NP_001152863.1	guanylate kinase isoform b
NM_001242839.1	NP_001229768.1	guanylate kinase isoform b
NM_001242840.3	NP_001229769.1	guanylate kinase isoform c

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables guanylate kinase activity	EXP EXP: Inferred from Experiment	8663313	GOA
enables guanylate kinase activity	IDA IDA: Inferred from direct assay	8663313	GOA
enables guanylate kinase activity	IMP IMP: Inferred from mutant phenotype	31201273	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in dGDP biosynthetic process	IMP IMP: Inferred from mutant phenotype	31201273	GOA
involved in purine nucleotide metabolic process	IDA IDA: Inferred from direct assay	8663313	GOA
involved in xenobiotic metabolic process	IDA IDA: Inferred from direct assay	6306664	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GUK1 Protein Structure

Guanylate_kin

0
100
197 a.a.

Protein Preferred Names	Protein Names
guanylate kinase	ATP:GMP phosphotransferase

GUK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GUK1	Q16774	TTC19	Homo sapiens	Q6DKK2	Anti Tag CoIP	33961781
Intra	GUK1	Q16774	TTC19	Homo sapiens	Q6DKK2	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cataract 6, Multiple Types	Ctpp1 Cataract 6 Multiple Types CTRCT6 Cataract, Posterior Polar, 1 Arcc2 Cataract, Age-Related Cortical, 2 Ctpa Ctpp Age Related Cortical Cataract 2 Posterior Polar Cataract 1 Posterior Polar Cataract, 1 Age-Related Cortical Cataract 2 Cataract Posterior Polar 1
Internal Hordeolum
Cataract 28	CTRCT28 Cataract, Age-Related Cortical, 1 Arcc1 Cataract 28, Age-Related Cortical, Susceptibility To Cataract 28, Age-Related Cortical Age-Related Cortical Cataract 1
Brugada Syndrome 4	BRGDA4 Brugada Syndrome, Type 4
Staphyloenterotoxemia	Staphylococcal Food Poisoning Staphylococcal Toxaemia Due To Food Staphyloenterotoxicosis
Ankylosis
Orbital Cellulitis	Cellulitis Of Orbit
Acute Orbital Inflammation	Acute Inflammation Of Orbit
Endocardium Disease
Ritter'S Disease	Staphylococcal Scalded Skin Syndrome Pemphigus Neonatorum Ritter Disease Dermatitis Exfoliativa Neonatorum Scalded Skin Syndrome Toxic Epidermal Necrolysis, Subcorneal Type Generalized Exfoliative Disease Ssss Ssss - [Staphylococcal Scalded Skin Syndrome]
Commensal Bacterial Infectious Disease
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05924	GUK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GUK1	VGNC	VGNC:29725
Felis catus	GUK1	VGNC	VGNC:67520
Mus musculus	GUK1	MGD	MGI:95871
Macaca mulatta	GUK1	VGNC	VGNC:73331
Canis familiaris	GUK1	VGNC	VGNC:54767
Rattus norvegicus	GUK1	RGD	RGD:1309638
Others	GUK1	NCBI