2. Gene
  3. Slc30a8 - solute carrier family 30 member 8 Gene

Slc30a8 - solute carrier family 30 member 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as ZnT-8

Gene ID: 299903 | Gene type: protein coding

About Slc30a8

Summary

Predicted to enable protein homodimerization activity and zinc ion transmembrane transporter activity. Involved in several processes, including Insulin secretion; ion homeostasis; and positive regulation of Insulin secretion. Located in cytoplasmic vesicle. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SLC30A8 (solute carrier family 30 member 8). [provided by Alliance of Genome Resources, Apr 2022]

Slc30a8 Products(1)

mRNA Protein Name
NM_001130538.1 NP_001124010.1 zinc transporter 8
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables zinc ion transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
19479076 RGD
Biological Process GO Annotation Evidence Reference Source
involved in insulin secretion IMP
IMP: Inferred from mutant phenotype
19479076 RGD
involved in intracellular zinc ion homeostasis IMP
IMP: Inferred from mutant phenotype
19479076 RGD
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
19479076 RGD
involved in regulation of vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
19479076 RGD
involved in response to glucose IMP
IMP: Inferred from mutant phenotype
19479076 RGD
involved in response to interleukin-1 IEP
IEP: Inferred from expression pattern
19243577 RGD
involved in response to type II interferon IEP
IEP: Inferred from expression pattern
19243577 RGD
involved in zinc ion import across plasma membrane IMP
IMP: Inferred from mutant phenotype
19479076 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc transporter 8

solute carrier family 30 (zinc transporter), member 8

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13186 SLC30A8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc30a8 NCBI NCBI:169026
Mus musculus Slc30a8 NCBI NCBI:239436