HABP2 - hyaluronan binding protein 2 Gene

Also Known as FSAP; HABP; PHBP; HGFAL; NMTC5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3026

About HABP2

Cytogenetic location: 10q25.3 Genomic coordinates (GRCh38): 10:113,550,831-113,589,602 (from NCBI)

This gene has 3 transcripts (splice variants), 225 orthologues, 5 paralogues and is associated with 3 phenotypes. Biased expression in liver (RPKM 158.0), gall bladder (RPKM 23.3) and 1 other tissue.

Summary

This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by hepatocytes and proteolytically processed to generate heavy and light chains that form the mature heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This extracellular protease binds hyaluronic acid and may play a role in the coagulation and fibrinolysis systems. Mutations in this gene are associated with nonmedullary thyroid Cancer and susceptibility to venous thromboembolism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

HABP2 Products (2)

mRNA Protein Name
NM_001177660.3 NP_001171131.1 hyaluronan-binding protein 2 isoform 2
NM_004132.5 NP_004123.1 hyaluronan-binding protein 2 isoform 1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables peptidase activity IDA
IDA: Inferred from direct assay
11217080 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within proteolysis IDA
IDA: Inferred from direct assay
11217080 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HABP2 Protein Structure

EGF

EGF: EGF-like domain (77 - 105)

EGF

EGF: EGF-like domain (154 - 185)

Kringle

Kringle: Kringle domain (194 - 276)

Trypsin

Trypsin: Trypsin (314 - 550)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 560 a.a.
Protein Preferred Names Protein Names

hyaluronan-binding protein 2

  • factor VII activating protein

Recombinant HABP2 Proteins

Cat. No. Product Name Accession Purity
HY-P70832 HABP2 Protein, Human (HEK293, His) Q14520-1 (F24-Q279) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Thyroid Cancer, Nonmedullary, 5

  • NMTC5

  • Thyroid Cancer, Non-Medullary, 5

  • Thyroid Cancer, Nonmedullary, 5, Susceptibility To

  • Cancer, Thyroid, Nonmedullary, Type 5
Thrombophilia Due To Thrombin Defect

  • Venous Thromboembolism

  • Venous Thrombosis

  • Thrombophilia Due To Factor 2 Defect

  • Thromboembolism

  • THPH1

  • Thromboembolism, Susceptibility To

  • Venous Thromboembolism, Susceptibility To

  • Venous Thrombosis, Protection Against

  • Prothrombin-Related Thrombophilia

  • Hyperprothrombinemia

  • Venous Thrombosis, Susceptibility To

  • Thrombophilia 1 Due To Thrombin Defect

  • F2-Related Thrombophilia

  • Factor Ii-Related Thrombophilia

  • Prothrombin 20210g>A Thrombophilia

  • Prothrombin G20210a Thrombophilia

  • Prothrombin Thrombophilia
Familial Papillary Or Follicular Thyroid Carcinoma

  • Fnmtc

  • Familial Pure Nonmedullary Thyroid Carcinoma

  • Familial Nonmedullary Thyroid Gland Carcinoma
Carotid Stenosis

  • Carotid Artery Stenosis

  • Stenosis, Carotid Artery
Melioidosis

  • Melioidosis, Susceptibility To

  • Acute And Fulminating Melioidosis

  • Nightcliff Gardener'S Disease

  • Pseudoglanders

  • Subacute And Chronic Melioidosis

  • Burkholderia Pseudomallei Infection

  • Whitmore Disease

  • Whitmore'S Disease

  • B Pseudomallei Infection

  • Epizootic Lymphangitis

  • Infection Due To Burkholderia Pseudomallei

  • Infection Due To Burkholderia Pseudomallei Nos

  • Infection Due To Malleomyces Pseudomallei

  • Infection Due To Pseudomonas Pseudomallei

  • Infection Due To Pseudomonas Pseudomallei Nos

  • Infection Due To Whitmore Bacillus

  • Stanton Disease
Palmoplantar Keratoderma, Punctate Type Ia

  • Keratosis Palmoplantaris Papulosa

  • Punctate Palmoplantar Keratoderma Type I

  • Ppkp1

  • Keratodermia Palmoplantaris Papulosa, Buschke-Fischer-Brauer Type

  • PPKP1A

  • Kppp1

  • Punctate Palmoplantar Keratoderma Type 1

  • Palmoplantar Keratoderma, Punctate Type 1a

  • Palmoplantar Keratoderma, Punctate Type I

  • Keratoderma, Palmoplantar, Punctate Type Ia

  • Punctate Palmoplantar Keratoderma Type 1a

  • Punctate Palmoplantar Keratoderma Type 1b

  • Brauer-Buschke-Fischer Syndrome

  • Keratoderma, Palmoplantar Punctate Type 1

  • Type I Punctate Palmoplantar Keratoderma

  • Buschke-Fischer-Brauer Syndrome

  • Keratoderma, Palmoplantar, Punctate 1a

  • Keratodermia Palmoplantaris Papulosa Buschke-Fischer-Brauer Type

  • Keratosis Punctate Palmoplantaris Buschke-Fisher-Brauer Type

  • Punctate Palmoplantar Keratoderma Type Ia

  • Keratoderma, Palmoplantar, Punctate Type 1

  • Keratoderma, Palmoplantar, Punctate, Type Ia
Bacterial Pneumonia

  • Gram-Negative Pneumonia

  • Pneumonia Due To Other Gram-Negative Bacteria

  • Pneumonia Bacterial

  • Pneumonia, Bacterial

  • Acute Bacillus Pneumonia

  • Acute Bacterial Pneumonia

  • Bacillus Double Pneumonia

  • Bacillus Pneumonia

  • Bacteria Pneumonia

  • Bacterial Double Pneumonia

  • Bacterial Lobar Pneumonia

  • Bacterial Purulent Pneumonia

  • Bronchopneumonia Due To Bacteria Other Than S. Pneumoniae And H. Influenzae
Acute Pyelonephritis

  • Apn - [Acute Pyelonephritis]
Dicer1 Syndrome

  • Pleuro-Pulmonary Blastoma Familial Tumor Susceptibility Syndrome

  • Pleuropulmonary Blastoma Familial Tumor Susceptibility Syndrome

  • Ppb Familial Tumor Susceptibility Syndrome

  • Dicer1-Related Pleuropulmonary Blastoma Cancer Predisposition Syndrome

  • Pleuro-Pulmonary Blastoma Familial Tumor Susceptibility

  • Dicer1-Related Pleuropulmonary Blastoma

  • Pleuropulmonary Blastoma Familial Tumor And Dysplasia Syndrome

  • Pleuropulmonary Blastoma Family Tumor Susceptibility Syndrome

  • Ppbftds

  • Doid:0081063
Carotid Artery Disease

  • Carotid Artery Diseases

  • Disorder Of Carotid Artery
Pyelitis
Carney Complex Variant

  • Carney Complex

  • Carney Syndrome

  • Carney Complex, Type 1

  • Lamb Syndrome

  • Name Syndrome

  • Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome

  • Carney Complex - Trismus - Pseudocamptodactyly Syndrome

  • Carney Complex, Type 2

  • Car

  • Cnc1

  • Carney Myxoma-Endocrine Complex

  • Myxoma - Spotty Pigmentation - Endocrine Overactivity

  • Myxoma, Spotty Pigmentation, And Endocrine Overactivity

  • Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome

  • Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome

  • Carney Complex-Trismus-Pseudocamptodactyly Syndrome

  • CACOV
Cowden Syndrome

  • Cowden Disease

  • Multiple Hamartoma Syndrome

  • Cowden'S Disease

  • Lhermitte-Duclos Disease

  • Cd

  • Cs

  • Mham

  • Dysplastic Gangliocytoma Of Cerebellum

  • Cowden'S Syndrome

  • Hamartoma Syndrome, Multiple
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05982 HABP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18282 Habp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24760 Habp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus HABP2 VGNC VGNC:55955
Felis catus HABP2 VGNC VGNC:67531
Rattus norvegicus HABP2 RGD RGD:1302979
Canis familiaris HABP2 VGNC VGNC:52994
Macaca mulatta HABP2 VGNC VGNC:73341
Mus musculus HABP2 MGD MGI:1196378
Others HABP2 NCBI