Tanc2 - tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 Gene

Rattus norvegicus

Also known as RGD1309285

Gene ID: 303599 | Gene type: protein coding

About Tanc2

Summary

Involved in dense core granule cytoskeletal transport; regulation of dendritic spine development; and regulation of dendritic spine morphogenesis. Located in dendritic spine. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Orthologous to human TANC2 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Tanc2 Products(1)

mRNA	Protein	Name
NM_001191653.1	NP_001178582.1	protein TANC2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	30021165	RGD
enables structural constituent of postsynaptic density	EXP EXP: Inferred from Experiment	30021165	RGD
enables structural constituent of postsynaptic density	IDA IDA: Inferred from direct assay	30021165	RGD
enables structural constituent of postsynaptic density	IMP IMP: Inferred from mutant phenotype	30021165	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in dense core granule cytoskeletal transport	IMP IMP: Inferred from mutant phenotype	30021165	RGD
involved in regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	30021165	RGD
involved in regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	30021165	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendritic spine	IDA IDA: Inferred from direct assay	30021165	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	30021165	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21068316	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21068316	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	30021165	RGD
is active in postsynaptic density	IMP IMP: Inferred from mutant phenotype	30021165	RGD
is active in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	21068316	RGD
is active in postsynaptic density, intracellular component	IMP IMP: Inferred from mutant phenotype	21068316	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein TANC2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14195	TANC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tanc2	NCBI	NCBI:26115

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