Tomm70 - translocase of outer mitochondrial membrane 70 Gene

Rattus norvegicus

Also known as TOM70; Tomm70a

Gene ID: 304017 | Gene type: protein coding

About Tomm70

Summary

Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; protein targeting to mitochondrion; and response to thyroxine. Is integral component of mitochondrial outer membrane. Part of mitochondrial outer membrane translocase complex. Used to study congestive heart failure. Biomarker of hypothyroidism. Orthologous to human TOMM70 (translocase of outer mitochondrial membrane 70). [provided by Alliance of Genome Resources, Apr 2022]

Tomm70 Products(1)

mRNA	Protein	Name
NM_212519.2	NP_997684.1	mitochondrial import receptor subunit TOM70

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11956321	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cell growth involved in cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	25022898	RGD
involved in positive regulation of protein targeting to mitochondrion	IMP IMP: Inferred from mutant phenotype	11956321	RGD
involved in protein targeting to mitochondrion	IMP IMP: Inferred from mutant phenotype	19401463	RGD
involved in response to thyroxine	IEP IEP: Inferred from expression pattern	10582581	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	11956321	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mitochondrial import receptor subunit TOM70

mitochondrial precursor proteins import receptor	translocase of outer membrane 70 kDa subunit
translocase of outer mitochondrial membrane protein 70

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14887	TOMM70 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tomm70	NCBI	NCBI:9868

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