Tomm70 - translocase of outer mitochondrial membrane 70 Gene

Also Known as TOM70; Tomm70a

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 304017

Summary

Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; protein targeting to mitochondrion; and response to thyroxine. Is integral component of mitochondrial outer membrane. Part of mitochondrial outer membrane translocase complex. Used to study congestive heart failure. Biomarker of hypothyroidism. Orthologous to human TOMM70 (translocase of outer mitochondrial membrane 70). [provided by Alliance of Genome Resources, Apr 2022]

Tomm70 Products (1)

mRNA Protein Name
NM_212519.2 NP_997684.1 mitochondrial import receptor subunit TOM70

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11956321 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell growth involved in cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
25022898 RGD
involved in positive regulation of protein targeting to mitochondrion IMP
IMP: Inferred from mutant phenotype
11956321 RGD
involved in protein targeting to mitochondrion IMP
IMP: Inferred from mutant phenotype
19401463 RGD
involved in response to thyroxine IEP
IEP: Inferred from expression pattern
10582581 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
11956321 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitochondrial import receptor subunit TOM70

  • mitochondrial precursor proteins import receptor

  • translocase of outer membrane 70 kDa subunit

  • translocase of outer mitochondrial membrane protein 70

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14887 TOMM70 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tomm70 NCBI NCBI:9868