TOMM70 - translocase of outer mitochondrial membrane 70 Gene

Homo sapiens

Also known as Tom70; TOMM70A

Gene ID: 9868 | Gene type: protein coding

About TOMM70

Cytogenetic location: 3q12.2 Genomic coordinates (GRCh38): 3:100,363,431-100,401,089 (from NCBI)

This gene has 3 transcripts (splice variants), 203 orthologues and 18 paralogues. Ubiquitous expression in brain (RPKM 23.1), thyroid (RPKM 20.6) and 25 other tissues.

Summary

This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. The protein interacts with the SARS-CoV and SARS-Cov-2 ORF9b proteins. [provided by RefSeq, Dec 2021]

TOMM70 Products(1)

mRNA	Protein	Name
NM_014820.5	NP_055635.3	mitochondrial import receptor subunit TOM70

TOMM70 Protein Structure

TPR_11

TPR_8

0
100
200
300
400
500
608 a.a.

Protein Preferred Names

Protein Names

mitochondrial import receptor subunit TOM70

mitochondrial precursor proteins import receptor

Related Diseases

Diseases

Alias

Myopathy, Centronuclear, 1

Autosomal Dominant Centronuclear Myopathy	CNM1
Centronuclear Myopathy 1	Ad-Cnm
Myopathy, Centronuclear, Autosomal Dominant	Myotubular Myopathy, Autosomal Dominant
Centronuclear Myopathy, Autosomal, Modifier Of	Autosomal Dominant Myotubular Myopathy
Dnm2-Related Centronuclear Myopathy	Centronuclear Myopathy Autosomal Dominant
Myopathies, Structural, Congenital	Myopathy, Centronuclear, Type 1

Microcephaly 7, Primary, Autosomal Recessive

MCPH7	Primary Autosomal Recessive Microcephaly 7
Microcephaly, Primary Autosomal Recessive, 7

Spastic Ataxia 5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14887	TOMM70 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TOMM70	VGNC	VGNC:78618
Canis familiaris	TOMM70	VGNC	VGNC:49630
Felis catus	TOMM70	VGNC	VGNC:66446
Rattus norvegicus	TOMM70	RGD	RGD:1303049
Mus musculus	TOMM70	MGD	MGI:106295
Bos taurus	TOMM70	VGNC	VGNC:49582

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