HCRT - hypocretin neuropeptide precursor Gene
Also Known as OX; PPOX; NRCLP1
Species: Homo sapiens
About HCRT
This gene has 1 transcript (splice variant), 175 orthologues and is associated with 3 phenotypes. Low expression observed in reference dataset.
Summary
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]
HCRT Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001524.1 | NP_001515.1 | hypocretin neuropeptide precursor precursor |
HCRT Protein Structure
Orexin: Prepro-orexin (1 - 130)
- 0
- 100
- 131 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
hypocretin neuropeptide precursor |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Narcolepsy 1 |
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| Narcolepsy |
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| Sleep Disorder |
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| Idiopathic Hypersomnia |
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| Narcolepsy 2 |
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| Recurrent Hypersomnia |
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| Apnea, Obstructive Sleep |
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| Eating Disorder |
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| Acute Disseminated Encephalomyelitis |
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| Sleep Apnea |
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| Restless Legs Syndrome |
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| Von Economo'S Disease |
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| Hypersomnia |
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| Kleine-Levin Hibernation Syndrome |
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| Mixed Sleep Apnea |
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| Periodic Limb Movement Disorder |
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| Anorexia Nervosa |
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| Central Sleep Apnea |
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| Dysthymic Disorder |
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| Prader-Willi Syndrome |
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| Major Depressive Disorder |
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| Leptin Deficiency Or Dysfunction |
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| Adjustment Disorder |
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| Huntington Disease |
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| Normal Pressure Hydrocephalus |
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| Neuromyelitis Optica |
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| Guillain-Barre Syndrome |
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| Delayed Sleep Phase Disorder |
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| Kluver-Bucy Syndrome |
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| Rem Sleep Behavior Disorder |
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| Phenylketonuria |
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| Migraine With Or Without Aura 1 |
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| Barbiturate Abuse |
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| Morphine Dependence |
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| Anxiety |
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| Hypothalamic Disease |
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| Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant |
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| Postpoliomyelitis Syndrome |
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| Body Mass Index Quantitative Trait Locus 11 |
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| Advanced Sleep Phase Syndrome |
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| Fatal Familial Insomnia |
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| Opiate Dependence |
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| Myotonic Dystrophy 1 |
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| Niemann-Pick Disease, Type C1 |
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| Withdrawal Disorder |
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| Disease Of Mental Health |
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| Anterograde Amnesia |
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| Dipsogenic Diabetes Insipidus |
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| Frontotemporal Dementia |
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| Supranuclear Palsy, Progressive, 1 |
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| Mood Disorder |
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| Holoprosencephaly |
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| Bruxism |
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| Post-Traumatic Stress Disorder |
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| Congenital Central Hypoventilation Syndrome |
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| Parkinson Disease, Late-Onset |
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| Substance Abuse |
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| Schizophrenia |
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| Demyelinating Disease |
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| Dystonia |
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| Specific Developmental Disorder |
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| Dementia, Lewy Body |
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| Attention Deficit-Hyperactivity Disorder |
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| Alzheimer Disease, Familial, 1 |
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| Hypertension, Essential |
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| Nervous System Disease |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | HCRT | MGD | MGI:1202306 |
| Macaca mulatta | HCRT | VGNC | VGNC:73355 |
| Rattus norvegicus | HCRT | RGD | RGD:2786 |
| Bos taurus | HCRT | VGNC | VGNC:29780 |
| Canis familiaris | HCRT | VGNC | VGNC:41622 |
| Others | HCRT | NCBI |