Farp1 - FERM, ARH/RhoGEF and pleckstrin domain protein 1 Gene

Rattus norvegicus

Gene ID: 306183 | Gene type: protein coding

About Farp1

Summary

Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including dendrite morphogenesis; retrograde trans-synaptic signaling by trans-synaptic protein complex; and synapse organization. Located in cytosol and dendrite. Is extrinsic component of cytoplasmic side of plasma membrane. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic membrane. Orthologous to human FARP1 (FERM, ARH/RhoGEF and pleckstrin domain protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Farp1 Products(1)

mRNA	Protein	Name
NM_001107287.1	NP_001100757.1	FERM, ARHGEF and pleckstrin domain-containing protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables guanyl-nucleotide exchange factor activity	IMP IMP: Inferred from mutant phenotype	23209303	RGD
enables small GTPase binding	IPI IPI: Inferred from physical interaction	23209303	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	23209303	RGD
involved in postsynaptic actin cytoskeleton organization	IDA IDA: Inferred from direct assay	23209303	RGD
involved in postsynaptic actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	23209303	RGD
involved in regulation of presynapse assembly	IDA IDA: Inferred from direct assay	23209303	RGD
involved in regulation of presynapse assembly	IMP IMP: Inferred from mutant phenotype	23209303	RGD
involved in retrograde trans-synaptic signaling by trans-synaptic protein complex	IDA IDA: Inferred from direct assay	23209303	RGD
involved in retrograde trans-synaptic signaling by trans-synaptic protein complex	IMP IMP: Inferred from mutant phenotype	23209303	RGD
involved in synapse assembly	IMP IMP: Inferred from mutant phenotype	23209303	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	23209303	RGD
located in cytosol	IDA IDA: Inferred from direct assay	23209303	RGD
located in dendrite	IDA IDA: Inferred from direct assay	23209303	RGD
is active in extrinsic component of postsynaptic membrane	IDA IDA: Inferred from direct assay	23209303	RGD
is active in extrinsic component of postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	23209303	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	23209303	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	23209303	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

FERM, ARHGEF and pleckstrin domain-containing protein 1

FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)	FERM, RhoGEF and pleckstrin domain-containing protein 1
FERMRhoGEF (Arhgef) and pleckstrin domain protein 1-like

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04746	FARP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Farp1	NCBI	NCBI:10160

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