Farp1 - FERM, ARH/RhoGEF and pleckstrin domain protein 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 306183

Summary

Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including dendrite morphogenesis; retrograde trans-synaptic signaling by trans-synaptic protein complex; and synapse organization. Located in cytosol and dendrite. Is extrinsic component of cytoplasmic side of plasma membrane. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic membrane. Orthologous to human FARP1 (FERM, ARH/RhoGEF and pleckstrin domain protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Farp1 Products (1)

mRNA Protein Name
NM_001107287.1 NP_001100757.1 FERM, ARHGEF and pleckstrin domain-containing protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity IMP
IMP: Inferred from mutant phenotype
23209303 RGD
enables small GTPase binding IPI
IPI: Inferred from physical interaction
23209303 RGD
Biological Process GO Annotation Evidence References Source
involved in dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
23209303 RGD
involved in postsynaptic actin cytoskeleton organization IDA
IDA: Inferred from direct assay
23209303 RGD
involved in postsynaptic actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
23209303 RGD
involved in regulation of presynapse assembly IDA
IDA: Inferred from direct assay
23209303 RGD
involved in regulation of presynapse assembly IMP
IMP: Inferred from mutant phenotype
23209303 RGD
involved in retrograde trans-synaptic signaling by trans-synaptic protein complex IDA
IDA: Inferred from direct assay
23209303 RGD
involved in retrograde trans-synaptic signaling by trans-synaptic protein complex IMP
IMP: Inferred from mutant phenotype
23209303 RGD
involved in synapse assembly IMP
IMP: Inferred from mutant phenotype
23209303 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
23209303 RGD
located in cytosol IDA
IDA: Inferred from direct assay
23209303 RGD
located in dendrite IDA
IDA: Inferred from direct assay
23209303 RGD
is active in extrinsic component of postsynaptic membrane IDA
IDA: Inferred from direct assay
23209303 RGD
is active in extrinsic component of postsynaptic membrane IMP
IMP: Inferred from mutant phenotype
23209303 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
23209303 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
23209303 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

FERM, ARHGEF and pleckstrin domain-containing protein 1

  • FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)

  • FERM, RhoGEF and pleckstrin domain-containing protein 1

  • FERMRhoGEF (Arhgef) and pleckstrin domain protein 1-like

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04746 FARP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Farp1 NCBI NCBI:10160