FARP1 - FERM, ARH/RhoGEF and pleckstrin domain protein 1 Gene

Also Known as CDEP; GLCC1; PLEKHC2; PPP1R75; FARP1-IT1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10160

About FARP1

Cytogenetic location: 13q32.2 Genomic coordinates (GRCh38): 13:98,142,172-98,455,176 (from NCBI)

This gene has 42 transcripts (splice variants), 281 orthologues and 10 paralogues. Ubiquitous expression in kidney (RPKM 19.9), thyroid (RPKM 13.0) and 24 other tissues.

Summary

This gene encodes a protein containing a FERM (4.2, exrin, radixin, moesin) domain, a Dbl homology domain, and two pleckstrin homology domains. These domains are found in guanine nucleotide exchange factors and proteins that link the Cytoskeleton to the cell membrane. The encoded protein functions in neurons to promote dendritic growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

FARP1 Products (3)

mRNA Protein Name
NM_001001715.4 NP_001001715.2 FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform 2
NM_001286839.2 NP_001273768.1 FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform 3
NM_005766.4 NP_005757.1 FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FARP1 Protein Structure

FERM_N

FERM_N: FERM N-terminal domain (44 - 121)

FERM_M

FERM_M: FERM central domain (126 - 230)

FERM_C

FERM_C: FERM C-terminal PH-like domain (234 - 323)

FA

FA: FERM adjacent (FA) (329 - 372)

RhoGEF

RhoGEF: RhoGEF domain (544 - 726)

PH

PH: PH domain (761 - 855)

PH

PH: PH domain (935 - 1029)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1045 a.a.
Protein Preferred Names Protein Names

FERM, ARHGEF and pleckstrin domain-containing protein 1

  • FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

FARP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FARP1 Q9Y4F1 PIH1D1 Homo sapiens Q9NWS0
Y2H Array
32296183
Intra
FARP1 Q9Y4F1 PIH1D1 Homo sapiens Q9NWS0
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nystagmus 3, Congenital, Autosomal Dominant

  • NYS3

  • Congenital Nystagmus 3

  • Autosomal Dominant Congenital Nystagmus 3
Premature Ovarian Failure 18

  • POF18

  • Primary Ovarian Insufficiency 18

  • Ovarian Failure, Premature, Type 18
Pathologic Nystagmus

  • Nystagmus
Congenital Nystagmus

  • Nystagmus, Congenital

  • Nystagmus Congenital
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04746 FARP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FARP1 RGD RGD:1305346
Macaca mulatta FARP1 VGNC VGNC:72614
Mus musculus FARP1 MGD MGI:2446173
Felis catus FARP1 VGNC VGNC:62149
Bos taurus FARP1 VGNC VGNC:28865
Canis familiaris FARP1 VGNC VGNC:40730
Others FARP1 NCBI