2. Gene
  3. Siva1 - SIVA1, apoptosis-inducing factor Gene

Siva1 - SIVA1, apoptosis-inducing factor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Siva; CD27bp

Gene ID: 30954 | Gene type: protein coding

About Siva1

Summary

Enables CD27 receptor binding activity; tumor necrosis factor receptor binding activity; and virus receptor activity. Predicted to be involved in several processes, including activation-induced cell death of T cells; negative regulation of NF-kappaB transcription factor activity; and positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Predicted to act upstream of or within apoptotic process. Predicted to be located in mitochondrion and nucleoplasm. Is expressed in cerebral cortex ventricular layer. Orthologous to human SIVA1 (SIVA1 Apoptosis inducing factor). [provided by Alliance of Genome Resources, Apr 2022]

Siva1 Products(2)

mRNA Protein Name
NM_001161737.1 NP_001155209.1 apoptosis regulatory protein Siva isoform 2
NM_013929.2 NP_038957.2 apoptosis regulatory protein Siva isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables CD27 receptor binding IPI
IPI: Inferred from physical interaction
12478477 MGI
enables tumor necrosis factor receptor binding IPI
IPI: Inferred from physical interaction
12478477 MGI
enables virus receptor activity IDA
IDA: Inferred from direct assay
11601913 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

apoptosis regulatory protein Siva

CD27-binding protein

Cd27 binding protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12957 SIVA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Siva1 NCBI NCBI:10572