SIVA1 - SIVA1 apoptosis inducing factor Gene

Also Known as SIVA; CD27BP; Siva-1; Siva-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10572

About SIVA1

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:104,753,147-104,759,654 (from NCBI)

This gene has 8 transcripts (splice variants) and 184 orthologues. Ubiquitous expression in bone marrow (RPKM 15.7), fat (RPKM 10.9) and 25 other tissues.

Summary

This gene encodes an E3 ubiquitin Ligase that regulates cell cycle progression, cell proliferation and Apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis. [provided by RefSeq, Sep 2018]

SIVA1 Products (2)

mRNA Protein Name
NM_006427.4 NP_006418.2 apoptosis regulatory protein Siva isoform 1
NM_021709.3 NP_068355.1 apoptosis regulatory protein Siva isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables CD27 receptor binding IPI
IPI: Inferred from physical interaction
9177220 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9177220 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
16683188 GOA
Biological Process GO Annotation Evidence References Source
involved in activation-induced cell death of T cells IDA
IDA: Inferred from direct assay
16491128 GOA
involved in extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
9177220 GOA
NOT involved in intrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
12011449 GOA
involved in intrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
12011449 GOA
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
16491128 GOA
involved in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IDA
IDA: Inferred from direct assay
15034012 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12011449 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
12011449 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
15034012 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIVA1 Protein Structure

Siva

Siva: Cd27 binding protein (Siva) (1 - 175)

  • 0
  • 100
  • 175 a.a.
Protein Preferred Names Protein Names

apoptosis regulatory protein Siva

  • CD27-binding (Siva) protein

SIVA1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SIVA1 O15304 PXMP2 Homo sapiens Q9NR77
Pull Down
16683188
Intra
SIVA1 O15304 BCL2L1 Homo sapiens Q07817-1
Anti Bait CoIP
12011449
Intra
SIVA1 O15304 CD27 Homo sapiens P26842
Anti Bait CoIP
9177220
Intra
SIVA1 O15304 BCL2L1 Homo sapiens Q07817
Pull Down
14739602
Cross
SIVA1 O15304 E7 Human papillomavirus P03129
Peptide Array
17348035
Cross
SIVA1 O15304 E7 Human papillomavirus P03129
Y2H
17348035
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12957 SIVA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SIVA1 RGD RGD:1561872
Mus musculus SIVA1 MGD MGI:1353606
Felis catus SIVA1 VGNC VGNC:65162
Bos taurus SIVA1 VGNC VGNC:34638
Others SIVA1 NCBI