2. Gene
  3. Pde8b - phosphodiesterase 8B Gene

Pde8b - phosphodiesterase 8B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RNPDE8B

Gene ID: 309962 | Gene type: protein coding

About Pde8b

Summary

Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity. Involved in negative regulation of Insulin secretion involved in cellular response to glucose stimulus. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease. Orthologous to human PDE8B (phosphodiesterase 8B). [provided by Alliance of Genome Resources, Apr 2022]

Pde8b Products(1)

mRNA Protein Name
NM_199268.2 NP_954889.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
17991719 RGD
involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
18706893 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

cAMP-specific cyclic nucleotide phosphodiesterase PDE8

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15426 PF-04957325 Inhibitor 99.55% Unkown
HY-135711 PDE8B-IN-1 99.91% Unkown
HY-117848 PDE8B-IN-1 hydrochloride Inhibitor / Unkown
HY-RS10245 PDE8B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde8b NCBI NCBI:8622