Spg11 - SPG11 vesicle trafficking associated, spatacsin Gene

Also Known as RGD1562529

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 311372

Summary

Predicted to be involved in several processes, including axo-dendritic transport; axon extension; and synaptic vesicle transport. Predicted to act upstream of or within phagosome-lysosome fusion involved in apoptotic cell clearance and walking behavior. Located in cytoplasm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2X; amyotrophic lateral sclerosis type 5; and hereditary spastic paraplegia 11. Orthologous to human SPG11 (SPG11 vesicle trafficking associated, spatacsin). [provided by Alliance of Genome Resources, Apr 2022]

Spg11 Products (1)

mRNA Protein Name
NM_001191571.1 NP_001178500.1 spatacsin

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21545838 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

spatacsin

  • SPG11, spatacsin vesicle trafficking associated

  • spastic paraplegia 11 (autosomal recessive)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13661 SPG11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spg11 NCBI NCBI:80208