2. Gene
  3. Spg11 - SPG11 vesicle trafficking associated, spatacsin Gene

Spg11 - SPG11 vesicle trafficking associated, spatacsin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RGD1562529

Gene ID: 311372 | Gene type: protein coding

About Spg11

Summary

Predicted to be involved in several processes, including axo-dendritic transport; axon extension; and synaptic vesicle transport. Predicted to act upstream of or within phagosome-lysosome fusion involved in apoptotic cell clearance and walking behavior. Located in cytoplasm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2X; amyotrophic lateral sclerosis type 5; and hereditary spastic paraplegia 11. Orthologous to human SPG11 (SPG11 vesicle trafficking associated, spatacsin). [provided by Alliance of Genome Resources, Apr 2022]

Spg11 Products(1)

mRNA Protein Name
NM_001191571.1 NP_001178500.1 spatacsin
Gene Ontology
  • Cellular Component
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21545838 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

spatacsin

SPG11, spatacsin vesicle trafficking associated

spastic paraplegia 11 (autosomal recessive)

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13661 SPG11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spg11 NCBI NCBI:80208