Trpa1 - transient receptor potential cation channel, subfamily A, member 1 Gene

Also Known as Anktm1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 312896

Summary

Enables osmolarity-sensing cation channel activity and voltage-gated Calcium Channel activity. Involved in several processes, including cellular response to caffeine; positive regulation of transport; and regulation of nervous system process. Located in apical plasma membrane and axon. Used to study asthma and diabetic neuropathy. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 1. Orthologous to human TRPA1 (transient receptor potential cation channel subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Trpa1 Products (1)

mRNA Protein Name
NM_207608.2 NP_997491.2 transient receptor potential cation channel subfamily A member 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables osmolarity-sensing monoatomic cation channel activity IDA
IDA: Inferred from direct assay
18279313 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
20231274 RGD
enables voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
14712238 RGD
Biological Process GO Annotation Evidence References Source
involved in calcium ion transmembrane import into cytosol IDA
IDA: Inferred from direct assay
14712238 RGD
involved in calcium ion transmembrane import into cytosol IMP
IMP: Inferred from mutant phenotype
31969645 RGD
involved in cellular response to caffeine IEP
IEP: Inferred from expression pattern
22319196 RGD
involved in cellular response to carbon dioxide IDA
IDA: Inferred from direct assay
20881114 RGD
involved in cellular response to cold IMP
IMP: Inferred from mutant phenotype
21068322 RGD
involved in cellular response to heat IMP
IMP: Inferred from mutant phenotype
22458587 RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
22701540 RGD
involved in positive regulation of monoatomic anion transport IMP
IMP: Inferred from mutant phenotype
22207576 RGD
involved in regulation of blood circulation IMP
IMP: Inferred from mutant phenotype
22133672 RGD
involved in regulation of neuronal action potential IMP
IMP: Inferred from mutant phenotype
20205719 RGD
involved in urinary bladder smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
21367919 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
22207576 RGD
located in axon IDA
IDA: Inferred from direct assay
18514429 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transient receptor potential cation channel subfamily A member 1

  • ankyrin-like with transmembrane domains protein 1

  • wasabi receptor

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-109061 Lazertinib Activator 99.87% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-171846 LY3526318 Inhibitor 99.92% Phase 2
HY-115877 GDC-0334 Antagonist / Phase 1

Pre-clinical Phase

Bioactive Molecules (28)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107436 LE135 Activator 99.0% Unkown
HY-W014421 AP-18 Inhibitor 99.61% Unkown
HY-109061B Lazertinib mesylate Activator 99.85% Unkown
HY-15065 Chembridge-5861528 Antagonist 99.12% Unkown
HY-120689 PF-04745637 Antagonist 99.60% Unkown
HY-N10319 Artepillin C Agonist 99.07% Unkown
HY-N7117 1,4-Cineole Activator 95.0% Unkown
HY-107535 AS1269574 Activator 99.84% Unkown
HY-P1073 ProTx-I Inhibitor 95.15% Unkown
HY-153711 TRPA1-IN-2 Inhibitor 99.55% Unkown
HY-172774 TRPV1 antagonist 10 Antagonist 98.54% Unkown
HY-175980 TRPA1 agonist-3 Agonist 99.78% Unkown
HY-15058 AMG2504 Antagonist / Unkown
HY-109061A Lazertinib mesylate hydrate Activator / Unkown
HY-179432 Cannabitwinol Modulator / Unkown
HY-N7965 Methyl kakuol Agonist / Unkown
HY-170652 ZQMT-10 Inhibitor / Unkown
HY-104062 AMG9678 Antagonist / Unkown
HY-162856 TRPV1-IN-2 Inhibitor / Unkown
HY-104061 AMG8788 Antagonist / Unkown
HY-127003 Neoambrosin Agonist / Unkown
HY-122692 TRPV4/TRPA1-IN-1 Inhibitor / Unkown
HY-181762 Multitarget AD-IN-6 Inhibitor / Unkown
HY-113488 8,9-Epoxyeicosatrienoic acid / Unkown
HY-187167 TRPA1-IN-5 Inhibitor / Unkown
HY-159134 TRPA1-IN-3 Inhibitor 99.66% Unkown
HY-N9503 Carvacryl acetate Activator 99.83% Unkown
HY-187618 GRC-17536 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trpa1 NCBI NCBI:8989