Adgrl3 - adhesion G protein-coupled receptor L3 Gene

Also Known as LEC3; Lphn3; CIRL-3; Gm1379; mKIAA0768; 5430402I23Rik; D130075K09Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 319387

Summary

Enables calcium ion binding activity. Involved in several processes, including locomotion involved in locomotory behavior; nervous system development; and response to cocaine. Acts upstream of or within positive regulation of synapse assembly. Located in axon and cell-cell junction. Is integral component of plasma membrane. Is active in glutamatergic synapse. Is expressed in ductus deferens; epididymis; esophagus; and ileum. Used to study attention deficit hyperactivity disorder. Orthologous to human ADGRL3 (adhesion G protein-coupled receptor L3). [provided by Alliance of Genome Resources, Apr 2022]

Adgrl3 Products (26)

mRNA	Protein	Name
NM_001347367.2	NP_001334296.1	adhesion G protein-coupled receptor L3 isoform 2 precursor
NM_001347368.2	NP_001334297.1	adhesion G protein-coupled receptor L3 isoform 3 precursor
NM_001347369.2	NP_001334298.1	adhesion G protein-coupled receptor L3 isoform 4 precursor
NM_001347371.2	NP_001334300.1	adhesion G protein-coupled receptor L3 isoform 5 precursor
NM_001359826.1	NP_001346755.1	adhesion G protein-coupled receptor L3 isoform 6
NM_001359828.1	NP_001346757.1	adhesion G protein-coupled receptor L3 isoform 7 precursor
NM_001359829.1	NP_001346758.1	adhesion G protein-coupled receptor L3 isoform 8 precursor
NM_001359830.1	NP_001346759.1	adhesion G protein-coupled receptor L3 isoform 9 precursor
NM_001359831.1	NP_001346760.1	adhesion G protein-coupled receptor L3 isoform 7 precursor
NM_001359832.1	NP_001346761.1	adhesion G protein-coupled receptor L3 isoform 10 precursor
NM_001359833.1	NP_001346762.1	adhesion G protein-coupled receptor L3 isoform 11 precursor
NM_001359834.1	NP_001346763.1	adhesion G protein-coupled receptor L3 isoform 12 precursor
NM_198702.3	NP_941991.1	adhesion G protein-coupled receptor L3 isoform 1 precursor
NM_001347367.2	NP_001334296.1	adhesion G protein-coupled receptor L3 isoform 2 precursor
NM_001347368.2	NP_001334297.1	adhesion G protein-coupled receptor L3 isoform 3 precursor
NM_001347369.2	NP_001334298.1	adhesion G protein-coupled receptor L3 isoform 4 precursor
NM_001347371.2	NP_001334300.1	adhesion G protein-coupled receptor L3 isoform 5 precursor
NM_001359826.1	NP_001346755.1	adhesion G protein-coupled receptor L3 isoform 6
NM_001359828.1	NP_001346757.1	adhesion G protein-coupled receptor L3 isoform 7 precursor
NM_001359829.1	NP_001346758.1	adhesion G protein-coupled receptor L3 isoform 8 precursor
NM_001359830.1	NP_001346759.1	adhesion G protein-coupled receptor L3 isoform 9 precursor
NM_001359831.1	NP_001346760.1	adhesion G protein-coupled receptor L3 isoform 7 precursor
NM_001359832.1	NP_001346761.1	adhesion G protein-coupled receptor L3 isoform 10 precursor
NM_001359833.1	NP_001346762.1	adhesion G protein-coupled receptor L3 isoform 11 precursor
NM_001359834.1	NP_001346763.1	adhesion G protein-coupled receptor L3 isoform 12 precursor
NM_198702.3	NP_941991.1	adhesion G protein-coupled receptor L3 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	26235031	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	25728924	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cell-cell adhesion via plasma-membrane adhesion molecules	IMP IMP: Inferred from mutant phenotype	22405201	MGI
involved in locomotion involved in locomotory behavior	IMP IMP: Inferred from mutant phenotype	22575564	MGI
involved in maintenance of postsynaptic specialization structure	IDA IDA: Inferred from direct assay	30792275	MGI
involved in maintenance of postsynaptic specialization structure	IMP IMP: Inferred from mutant phenotype	30792275	MGI
involved in neuron migration	IMP IMP: Inferred from mutant phenotype	25728924	MGI
acts upstream of or within positive regulation of synapse assembly	IDA IDA: Inferred from direct assay	24613359	MGI
involved in response to cocaine	IMP IMP: Inferred from mutant phenotype	22575564	MGI
involved in synapse assembly	IDA IDA: Inferred from direct assay	30792275	MGI
involved in synapse assembly	IMP IMP: Inferred from mutant phenotype	22405201	MGI
involved in synapse organization	IDA IDA: Inferred from direct assay	24739570	MGI
involved in synapse organization	IMP IMP: Inferred from mutant phenotype	24739570	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	30792275	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	30792275	MGI
located in axon	IDA IDA: Inferred from direct assay	22405201	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	22405201	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	24739570	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	24739570	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	22405201	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	30792275	MGI
is active in postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	30792275	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
adhesion G protein-coupled receptor L3	G protein coupled receptor Lec3 calcium-independent alpha-latrotoxin receptor homolog 3 latrophilin-3 lectomedin-3

Adgrl3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Adgrl3	Q80TS3	Flrt2	Mus musculus	Q8BLU0	SPR	25728924
Intra	Adgrl3	Q80TS3	Flrt3	Mus musculus	Q8BGT1	ITC	26235031
Intra	Adgrl3	Q80TS3	Flrt3	Mus musculus	Q8BGT1	X-Ray Diffraction	26235031
Intra	Adgrl3	Q80TS3	Flrt3	Mus musculus	Q8BGT1	Solution Sedimentation	26235031
Intra	Adgrl3	Q80TS3	Flrt3	Mus musculus	Q8BGT1	GMS	26235031
Intra	Adgrl3	Q80TS3	Flrt3	Mus musculus	Q8BGT1	H1-H2 MS	26235031

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00363	ADGRL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adgrl3	NCBI	NCBI:23284