Zdhhc17 - zinc finger, DHHC domain containing 17 Gene

Mus musculus

Also known as Hip14; DHHC-17; A230053P19Rik; D130071N24Rik

Gene ID: 320150 | Gene type: protein coding

About Zdhhc17

Summary

Enables palmitoyltransferase activity and signaling receptor binding activity. Involved in axonogenesis; peptidyl-L-cysteine S-palmitoylation; and regulation of signal transduction. Acts upstream of or within protein palmitoylation. Located in Golgi apparatus. Is expressed in several structures, including early conceptus; heart; and oocyte. Used to study Huntington's disease. Orthologous to human ZDHHC17 (zinc finger DHHC-type palmitoyltransferase 17). [provided by Alliance of Genome Resources, Apr 2022]

Zdhhc17 Products(3)

mRNA	Protein	Name
NM_001359622.1	NP_001346551.1	palmitoyltransferase ZDHHC17 isoform 2
NM_001359624.1	NP_001346553.1	palmitoyltransferase ZDHHC17 isoform 3
NM_172554.2	NP_766142.2	palmitoyltransferase ZDHHC17 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables palmitoyltransferase activity	IDA IDA: Inferred from direct assay	15603741	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	25253725	MGI
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	26232532	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in axonogenesis	IMP IMP: Inferred from mutant phenotype	26232532	MGI
involved in peptidyl-L-cysteine S-palmitoylation	IDA IDA: Inferred from direct assay	28167757	MGI
acts upstream of or within protein palmitoylation	IDA IDA: Inferred from direct assay	15603741	MGI
involved in protein palmitoylation	IDA IDA: Inferred from direct assay	18596047	MGI
involved in regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	26232532	MGI
involved in regulation of modification of synapse structure, modulating synaptic transmission	IDA IDA: Inferred from direct assay	24277827	MGI
involved in regulation of modification of synapse structure, modulating synaptic transmission	IMP IMP: Inferred from mutant phenotype	24277827	MGI
involved in regulation of neurotrophin TRK receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	26232532	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	18596047	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	24277827	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	24277827	MGI
is active in perforant pathway to dendrate granule cell synapse	IDA IDA: Inferred from direct assay	24277827	MGI
is active in perforant pathway to dendrate granule cell synapse	IMP IMP: Inferred from mutant phenotype	24277827	MGI
is active in postsynaptic Golgi apparatus	IDA IDA: Inferred from direct assay	15603740	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

palmitoyltransferase ZDHHC17

DHHC domain-containing cysteine-rich protein 17	acyltransferase ZDHHC17
acyltransferase ZDHHC7	huntingtin interacting protein 14
zinc finger DHHC domain-containing protein 17

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16016	ZDHHC17 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Zdhhc17	NCBI	NCBI:23390

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