Dennd1b - DENN domain containing 1B Gene

Mus musculus

Also known as 4632404N19Rik; 4930467M19Rik; 6820401H01Rik; F730008N07Rik

Gene ID: 329260 | Gene type: protein coding

About Dennd1b

Summary

Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in endocytic recycling; positive regulation of GTPase activity; and positive regulation of immune response. Predicted to be located in cytoplasmic vesicle. Predicted to be active in cytosol and nuclear speck. Orthologous to human DENND1B (DENN domain containing 1B). [provided by Alliance of Genome Resources, Apr 2022]

Dennd1b Products(2)

mRNA	Protein	Name
NM_001166501.1	NP_001159973.1	DENN domain-containing protein 1B isoform 1
NM_181347.3	NP_851992.1	DENN domain-containing protein 1B isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables guanyl-nucleotide exchange factor activity	IMP IMP: Inferred from mutant phenotype	26774822	MGI
enables small GTPase binding	IPI IPI: Inferred from physical interaction	26774822	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	26774822	MGI
involved in endocytic recycling	IMP IMP: Inferred from mutant phenotype	26774822	MGI
involved in positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	26774822	MGI
involved in positive regulation of T-helper 2 cell cytokine production	IMP IMP: Inferred from mutant phenotype	26774822	MGI
involved in regulation of immune response	IMP IMP: Inferred from mutant phenotype	26774822	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

DENN domain-containing protein 1B

ASL1/9AS1-1 fusion	DENN/MADD domain containing 1B
connecdenn 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03686	DENND1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dennd1b	NCBI	NCBI:163486

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