SLC35D3 - solute carrier family 35 member D3 Gene

Also Known as FRCL1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 340146

About SLC35D3

Cytogenetic location: 6q23.3 Genomic coordinates (GRCh38): 6:136,922,301-136,925,660 (from NCBI)

This gene has 1 transcript (splice variant), 196 orthologues and 9 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable antiporter activity and pyrimidine nucleotide-sugar transmembrane transporter activity. Predicted to be involved in carbohydrate transport and pyrimidine nucleotide-sugar transmembrane transport. Predicted to act upstream of or within energy homeostasis and positive regulation of protein exit from endoplasmic reticulum. Predicted to be located in early endosome and endoplasmic reticulum. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]

SLC35D3 Products (1)

mRNA	Protein	Name
NM_001008783.3	NP_001008783.1	solute carrier family 35 member D3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables UDP-glucose transmembrane transporter activity	IDA IDA: Inferred from direct assay	34269178	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in UDP-glucose transmembrane transport	IDA IDA: Inferred from direct assay	34269178	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	34269178	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC35D3 Protein Structure

TPT

0
100
200
300
416 a.a.

Protein Preferred Names	Protein Names
solute carrier family 35 member D3	frc, fringe-like 1

SLC35D3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC35D3	Q5M8T2	GPCPD1	Homo sapiens	Q9NPB8	Anti Tag CoIP	33961781
Intra	SLC35D3	Q5M8T2	GPCPD1	Homo sapiens	Q9NPB8	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Thrombocytopenia With Beta-Thalassemia, X-Linked	XLTT Thrombocytopenia, Platelet Dysfunction, Hemolysis, And Imbalanced Globin Synthesis Beta-Thalassemia-X-Linked Thrombocytopenia Syndrome Gata1-Related X-Linked Cytopenia X-Linked Thrombocytopenia With Beta-Thalassemia Thrombocytopenia Platelet Dysfunction Hemolysis And Imbalanced Globin Synthesis
Prostate Small Cell Carcinoma	Small Cell Carcinoma Of Prostate Prostate Oat Cell Carcinoma
Intellectual Developmental Disorder, Autosomal Dominant 56	Mental Retardation, Autosomal Dominant 56 MRD56 Autosomal Dominant Mental Retardation 56 Autosomal Dominant Intellectual Developmental Disorder 56 Autosomal Dominant Intellectual Developmental Disorder-56
Developmental And Epileptic Encephalopathy 48	DEE48 Epileptic Encephalopathy, Early Infantile, 48 Eiee48 Developmental And Epileptic Encephalopathy, 48 Early Infantile Epileptic Encephalopathy 48
Psoriasis 15	Psors15
Hermansky-Pudlak Syndrome	Hps Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells Hermanski-Pudlak Syndrome Hermansky Pudlak Syndrome Platelet Storage Pool Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13203	SLC35D3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLC35D3	VGNC	VGNC:34829
Rattus norvegicus	SLC35D3	RGD	RGD:1309428
Felis catus	SLC35D3	VGNC	VGNC:65328
Canis familiaris	SLC35D3	VGNC	VGNC:46372
Mus musculus	SLC35D3	MGD	MGI:1923407
Macaca mulatta	SLC35D3	VGNC	VGNC:104427
Others	SLC35D3	NCBI