APOC2 - apolipoprotein C2 Gene

Also Known as APO-CII; APOC-II

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 344

About APOC2

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:44,946,051-44,949,565 (from NCBI)

This gene has 5 transcripts (splice variants), 121 orthologues and is associated with 3 phenotypes. Restricted expression toward liver (RPKM 1243.9).

Summary

This gene encodes a lipid-binding protein belonging to the Apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein Lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with Other related Apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream Apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]

APOC2 Products (1)

mRNA	Protein	Name
NM_000483.5	NP_000474.2	apolipoprotein C-II precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	28229588	GOA
enables lipase inhibitor activity	IDA IDA: Inferred from direct assay	182536	GOA
enables lipid binding	IDA IDA: Inferred from direct assay	10727238	GOA
enables lipoprotein lipase activator activity	IDA IDA: Inferred from direct assay	270715	GOA
enables molecular function activator activity	EXP EXP: Inferred from Experiment	15209504	GOA
enables phospholipase activator activity	IDA IDA: Inferred from direct assay	10727238	GOA
enables phospholipase binding	IPI IPI: Inferred from physical interaction	10727238	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cholesterol efflux	IDA IDA: Inferred from direct assay	11162594	GOA
involved in chylomicron remnant clearance	IDA IDA: Inferred from direct assay	4020294	GOA
involved in high-density lipoprotein particle clearance	IMP IMP: Inferred from mutant phenotype	15778093	GOA
involved in negative regulation of cholesterol transport	IMP IMP: Inferred from mutant phenotype	15778093	GOA
involved in negative regulation of lipid metabolic process	IDA IDA: Inferred from direct assay	182536	GOA
involved in negative regulation of receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	1917954	GOA
involved in negative regulation of very-low-density lipoprotein particle clearance	IDA IDA: Inferred from direct assay	1917954	GOA
involved in phospholipid efflux	IDA IDA: Inferred from direct assay	11162594	GOA
involved in positive regulation of fatty acid biosynthetic process	IDA IDA: Inferred from direct assay	10727238	GOA
involved in positive regulation of lipoprotein lipase activity	IDA IDA: Inferred from direct assay	10727238	GOA
involved in positive regulation of phospholipase activity	IDA IDA: Inferred from direct assay	10727238	GOA
involved in positive regulation of phospholipid catabolic process	IDA IDA: Inferred from direct assay	10727238	GOA
involved in positive regulation of triglyceride catabolic process	IDA IDA: Inferred from direct assay	10727238	GOA
involved in triglyceride homeostasis	IMP IMP: Inferred from mutant phenotype	17018885	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of chylomicron	IDA IDA: Inferred from direct assay	8245722	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	10727238	GOA
part of intermediate-density lipoprotein particle	IDA IDA: Inferred from direct assay	17336988	GOA
part of low-density lipoprotein particle	IDA IDA: Inferred from direct assay	8245722	GOA
part of spherical high-density lipoprotein particle	IDA IDA: Inferred from direct assay	16682745	GOA
part of very-low-density lipoprotein particle	IDA IDA: Inferred from direct assay	8245722	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOC2 Protein Structure

Apo-CII

0
101 a.a.

Protein Preferred Names	Protein Names
apolipoprotein C-II

APOC2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	APOC2	P02655	TTPA	Homo sapiens	P49638	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant APOC2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7529	APOC2 Protein, Human (His, solution)	P02655 (T23-E101)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Apolipoprotein C-Ii Deficiency	Apoc2 Deficiency Hyperlipoproteinemia, Type Ib Apolipoprotein C-Ii C-Ii Anapolipoproteinemia Hyperlipoproteinemia 1b HLPP1B Hyperlipoproteinemia Type Ib Apolipoprotein C-Ii Variant Apolipoprotein C2 Deficiency Familial Apolipoprotein C-Ii Deficiency
Familial Apolipoprotein C-Ii Deficiency	Familial Apoc-Ii Deficiency Familial Apoc2 Deficiency C-Ii Anapolipoproteinemia Hyperlipoproteinemia, Type 1b Hyperlipoproteinemia, Type Ib Hyperlipoproteinemia Type I
Pancreatitis	Mumps Pancreatitis
Familial Hyperlipidemia	Familial Hyperlipoproteinemia Hyperlipidaemia Hyperlipoproteinemias Hyperlipidemia Hyperlipemia Hyperlipidemias
Hyperlipoproteinemia, Type V	Hyperlipoproteinemia Type V Hyperchylomicronemia, Late-Onset Familial Type 5 Hyperlipoproteinemia Hyperchylomicronemia With Hyperprebetalipoproteinemia, Familial Hyperlipidemia, Type V Hyperlipemia, Mixed Hyperlipemia, Combined Fat And Carbohydrate-Induced Familial Hyperlipoproteinemia Type V Fredrickson Type V Lipaemia Hyperlipoproteinemia Type 5 Hyperchylomicronemia Late Onset Hyperlipemia Combined Fat And Carbohydrate-Induced Hyperlipemia Mixed Hyperlipidemia Type V Mixed Hyperlipemia Type V Hyperlipoproteinemia Hyperlipoproteinemia 5 HLPP5 Hyperlipidemia, Familial Combined Mixed Hyperlipidemia
Hyperlipoproteinemia, Type Iv	Hyperlipoproteinemia Type Iv Carbohydrate-Inducible Hyperlipemia Endogenous Hyperlipidaemia Familial Hypertriglyceridemia Fredrickson Type Iv Hyperlipoproteinemia Fredrickson Type Iv Lipidaemia Fredrickson Type Iv Lipidemia Vldl Hyperlipoproteinemia Hyperlipoproteinemia Type 4 Carbohydrate Inducible Hyperlipemia Familial Type Iv Hyperlipoproteinemia Familial Hyperlipoproteinemia Type Iv
Hypertriglyceridemia 1	Hypertriglyceridemia Hypertriglyceridemia, Familial Hypertriglyceridemia, Susceptibility To HYTG1 FHTR Hypertriglyceridemias Familial
Acute Pancreatitis	Pancreatitis Pancreatitis, Acute Necrotizing Pancreatitis Nos Acute Pancreas Inflammation
Familial Lipoprotein Lipase Deficiency	Familial Lpl Deficiency Familial Hyperchylomicronemia Hyperlipoproteinemia Type I Familial Hyperlipoproteinemia Type I Hyperchylomicronemia Burger-Grutz Syndrome Endogenous Hypertriglyceridaemia Familial Fat-Induced Hypertriglyceridemia Lipd Deficiency Lpl Deficiency Lipase D Deficiency Lipoprotein Lipase Deficiency, Familial Familial Chylomicronemia Syndrome Fredrickson Type I Hyperlipoproteinemia Fredrickson Type I Lipaemia Hypercholesterinaemic Xanthomatosis Mixed Hyperglyceridemia Lipoprotein Lipase Deficiency Type I Hyperlipoproteinemia Hyperlipoproteinemia Type Ia Familial Hyperlipo-Proteinemia Type 1
Hyperlipoproteinemia, Type I	Lipoprotein Lipase Deficiency Familial Chylomicronemia Syndrome Lpl Deficiency Hyperchylomicronemia, Familial Hyperlipemia, Idiopathic, Burger-Grutz Type Hyperlipemia, Essential Familial Lipase D Deficiency Lipd Deficiency Hyperlipoproteinemia, Type Ia Chylomicronemia, Familial High Density Lipoprotein Cholesterol Level Qtl 11 Hyperlipoproteinemia Type 1 Hyperlipoproteinemia 1 HLPP1 Lipoprotein Lipase Hyperlipoproteinemia Type I Familial Hyperchylomicronemia Syndrome
Amyloidosis, Familial Visceral	Ostertag Type Amyloidosis German Type Amyloidosis Familial Renal Amyloidosis Amyloidosis Viii Amyloidosis, 3 Or More Types Familial Visceral Amyloidosis Familial Amyloid Nephropathy Hereditary Amyloid Nephropathy Amyloidosis, Familial Renal Amyloidosis, Systemic Nonneuropathic Amyloidosis Familial Visceral Amyloidosis 8 Amyloidosis, Ostertag Type Hereditary Amyloidosis With Primary Renal Involvement Hereditary Renal Amyloidosis Renal Amyloidosis Amyloidosis, Renal Systemic Nonneuropathic Amyloidosis Amyloidosis Familial Renal Amyloidosis Systemic Nonneuropathic Hereditary Amyloidosis With Primary Renal Involement AMYL8 Systemic Non-Neuropathic Amyloidosis Amyloid Nephropathy
Apolipoprotein A-Iv Associated Amyloidosis	Aapoaiv Amyloidosis Renal Aapoaiv Amyloidosis Apolipoprotein A-Iv Amyloidosis
Hyperlipoproteinemia, Type Iii	Hyperlipoproteinemia Type Iii Broad-Betalipoproteinemia Floating-Betalipoproteinemia Familial Type 3 Hyperlipoproteinemia Broad Beta Disease Familial Hyperbeta- And Prebetalipoproteinemia Familial Hypercholesterolemia With Hyperlipemia Hyperlipemia With Familial Hypercholesterolemic Xanthomatosis Coronary Artery Disease, Severe, Susceptibility To Coronary Artery Disease, Severe Hyperlipidemia Type 3 Familial Dysbetalipoproteinemia Hyperlipoproteinemia Type 3 Coronary Artery Disease Apolipoprotein E, Deficiency Or Defect Of Dysbetalipoproteinemia Due To Defect In Apolipoprotein E-D Carbohydrate Induced Hyperlipemia Familial Hypercholesterolaemia With Hyperlipaemia Remnant Hyperlipidemia Remnant Removal Disease Dysbetalipoproteinemia Broad-Beta Disease Familial Dyslipidemia Type 3 Hlp Type 3 Remnant Hyperlipoproteinemia Familial Hyperlipoproteinemia Type Iii CAD Hyperlipoproteinemia 3 HLPP3 Deficiency Or Defect Of Apolipoprotein E Dysbetalipoproteinemia Due To Defect In Apolipoprotein E Coronary Arteriosclerosis Coronary Heart Disease
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Vascular Anomaly Spinal Cord Vascular Diseases Vascular Tissue Disease
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Hypobetalipoproteinemia, Familial, 1	Hypobetalipoproteinemia Familial Hypobetalipoproteinemia 1 Familial Hypobetalipoproteinemia FHBL1 Hypobetalipoproteinemia, Familial Fhbl Acanthocytosis With Hypobetalipoproteinemia Hypobetalipoproteinemias Hypobetalipoproteinemia, Normotriglyceridemic Hypo-Beta-Lipoproteinemia Hypobetalipoprotéinemia, Familial Normotriglyceridemic Hypobetalipoproteinemia Hypobetalipoproteinemia, Familial, Type 1
Hypolipoproteinemia	Hypolipoproteinaemia Lipoprotein Deficiencies Lipoprotein Disorder Hypolipoproteinemias Lipoprotein Lipoprotein Deficiency Hypolipidaemia Lipoprotein Deficiency Disorder High-Density Lipoid Deficiency High-Density Lipoprotein Deficiency Dyslipidaemia, Depressed Hdl Cholesterol
Diabetes Mellitus	Diabetes
Hyperlipidemia, Familial Combined, 3	Familial Combined Hyperlipidemia Combined Hyperlipidemia, Familial Mixed Hyperlipidaemia FCHL3 Hyperlipidemia, Familial Combined Familial Multiple Lipoprotein-Type Hyperlipidemia Hyperbetalipoproteinemia With Prebetalipoproteinemia Type Iib Hyperlipoproteinemia Hyperlipidemia Familial Combined Hyperlipoproteinemia Type Iib Mixed Hyperlipemia Hyperlipidaemia, Group C Familial Hypercholesterolaemia With Hyperlipaemia Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia Hyperbetalipoproteinaemia With Prebetalipoproteinaemia Hypercholesterolaemia With Endogenous Hyperglyceridaemia Prebetalipoproteinemia Hyperbetalipoproteinaemia Remnant Hyperlipoproteinemia
Sitosterolemia	Phytosterolemia Beta-Sitosterolemia Plant Sterol Storage Disease Phytosterolæmia Sitosterolæmia Retention Of Dietary Cholesterol And Abnormal Retention Of Non-Cholesterol Sterols In The Body Phytosterolaemia Sitosterolaemia Sitosterolemia With Xanthomatosis
Hypoalphalipoproteinemia, Primary, 1	Familial Hdl Deficiency Fha High Density Lipoprotein Deficiency Familial Hypoalphalipoproteinemia Hypoalphalipoproteinemia, Familial Hdld Fhd Hdl Deficiency, Type 2 Primary Hypoalphalipoproteinemia 1 Hdl Cholesterol, Low Serum Hdlc Hdl Deficiency, Familial, 1 Hypoalphalipoproteinemia, Primary Low Serum Hdl Cholesterol Primary Hypoalphalipoproteinemia FHA1 Hdld2 High Density Lipoprotein Deficiency 2 Hypoalphalipoproteinemias Apolipoprotein A-I Deficiency
Lipid Metabolism Disorder	Dyslipidemia Disorder Of Fatty Acid Metabolism Lipid Metabolism Disorders Fatty Acid Metabolism Disorder Disorder Of Lipid Metabolism Abnormality Of Lipid Metabolism Lipid Metabolism, Inborn Errors Dyslipidemias Disorders Of Lipid Metabolism Congenital Disorders Of Lipid Metabolism Inherited Disorders Of Lipid Metabolism
Familial Hypercholesterolemia	Hyperlipoproteinemia Type Iia Familial Hyperbetalipoproteinaemia Familial Hypercholesteremia Fredrickson Type Iia Hyperlipoproteinemia Fredrickson Type Iia Lipidaemia Hyperbetalipoproteinemia Type Ii Hyperlipidemia Familial Hypercholesterolæmia Familial Hypercholesterolaemia Fh Hypercholesterolemia Familial Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00845	APOC2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	APOC2	VGNC	VGNC:56913
Bos taurus	APOC2	VGNC	VGNC:52176
Mus musculus	APOC2	MGD	MGI:88054
Rattus norvegicus	APOC2	RGD	RGD:2135
Others	APOC2	NCBI