FOXI3 - forkhead box I3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 344167

About FOXI3

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:88,446,787-88,452,693 (from NCBI)

This gene has 1 transcript (splice variant), 81 orthologues and 42 paralogues. Restricted expression toward placenta (RPKM 3.1).

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

FOXI3 Products (1)

mRNA Protein Name
NM_001135649.3 NP_001129121.1 forkhead box protein I3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
37041148 GOA
Biological Process GO Annotation Evidence References Source
involved in pharyngeal system development IMP
IMP: Inferred from mutant phenotype
37041148 GOA
Cellular Component GO Annotation Evidence References Source
is active in nucleus IDA
IDA: Inferred from direct assay
37041148 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

forkhead box protein I3

Related Diseases

Diseases Alias
Ectopic Thymus
T-Cell Immunodeficiency With Thymic Aplasia

  • Nezelof Syndrome

  • T-Lymphocyte Deficiency

  • TIDTA

  • Immune Defect Due To Absence Of Thymus

  • Thymic Aplasia

  • Nezelof'S Syndrome

  • Thymic Dysplasia With Normal Immunoglobulins

  • Thymic Aplasia Syndrome

  • T-Lymphocyte Immunodeficiency
Mucinoses
Microphthalmia, Syndromic 3

  • MCOPS3

  • Aeg Syndrome

  • Microphthalmia And Esophageal Atresia Syndrome

  • Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome

  • Anophthalmia-Esophageal-Genital Syndrome

  • Optic Nerve Hypoplasia And Abnormalities Of The Central Nervous System

  • Syndromic Microphthalmia 3

  • Sox2 Anophthalmia Syndrome

  • Anophthalmia Clinical With Associated Anomalies

  • Anophthalmia Esophageal Genital Syndrome

  • Anophthalmia Microphthalmia Esophageal Atresia

  • Syndromic Microphthalmia Type 3

  • Sox2-Related Eye Disorders

  • Anophthalmia, Clinical, With Associated Anomalies

  • Syndromic Microphthalmia, Type 3

  • Microphthalmia, Syndromic, 3

  • Anophthalmia/Microphthalmia-Esophageal Atresia

  • Microphthalmia Syndromic, Type 3
St2 Diffuse Large B-Cell Lymphoma

  • St2 Dlbcl

  • Doid:0081068
Alopecia Universalis Congenita

  • Alopecia Universalis

  • ALUNC

  • Atrichia, Generalized

  • Au

  • Alopecia Areata Universalis

  • Atrichia Generalized
Ectodermal Dysplasia 10b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive

  • Hypohidrotic Ectodermal Dysplasia

  • Hed

  • Anhidrotic Ectodermal Dysplasia

  • Ectodermal Dysplasia, Hypohidrotic

  • Eda

  • Christ-Siemens-Touraine Syndrome

  • ECTD10B

  • Ectodermal Dysplasia Anhidrotic

  • Ectodermal Dysplasia, Anhidrotic

  • Cst Syndrome

  • Ectodermal Dysplasia Hypohidrotic Autosomal Recessive

  • Dysplasia, Ectodermal, Type 10b, Hypohidrotic/Hair/Tooth, Autosomal Recessive

  • Dysplasia, Ectodermal, Hypohidrotic

  • Ectodermal Dysplasia 11b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive

  • Ectodermal Dysplasia 3, Anhidrotic

  • Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive
Tooth Agenesis

  • Oligodontia

  • Hypodontia

  • Selective Tooth Agenesis

  • Tooth Agenesis, Selective

  • Familial Tooth Agenesis

  • Anodontia

  • Congenital Absence Of One Tooth
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P4184 Isotocin / Unkown
HY-P4184A Isotocin acetate / Unkown
HY-RS05055 FOXI3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris FOXI3 VGNC VGNC:40953
Macaca mulatta FOXI3 VGNC VGNC:72606
Rattus norvegicus FOXI3 RGD RGD:1561816
Bos taurus FOXI3 VGNC VGNC:54433
Mus musculus FOXI3 MGD MGI:3511278
Felis catus FOXI3 VGNC VGNC:80103
Others FOXI3 NCBI