Fga - fibrinogen alpha chain Gene

Also Known as Fba5e; Ac1873

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 361969

Summary

Predicted to enable structural molecule activity. Predicted to contribute to cell adhesion molecule binding activity and signaling receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; liver regeneration; and response to peptide hormone. Located in blood microparticle and rough endoplasmic reticulum. Used to study asthma; brain ischemia; disseminated intravascular coagulation; and thrombocytopenia. Biomarker of acute kidney failure; disseminated intravascular coagulation; pancreatitis; pulmonary embolism; and pulmonary emphysema. Human ortholog(s) of this gene implicated in brain small vessel disease; congenital afibrinogenemia; familial visceral amyloidosis; and thrombophilia. Orthologous to human FGA (fibrinogen alpha chain). [provided by Alliance of Genome Resources, Apr 2022]

Fga Products (2)

mRNA Protein Name
NM_001008724.2 NP_001008724.1 fibrinogen alpha chain isoform 1 precursor
NM_052797.1 NP_434684.1 fibrinogen alpha chain isoform 2 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in acute-phase response IEP
IEP: Inferred from expression pattern
6185147 RGD
involved in cellular response to granulocyte colony-stimulating factor IEP
IEP: Inferred from expression pattern
9488469 RGD
involved in cellular response to interleukin-6 IEP
IEP: Inferred from expression pattern
9488469 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
2440878 RGD
involved in envenomation resulting in modulation of blood coagulation in another organism IEP
IEP: Inferred from expression pattern
6896326 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
3817019 RGD
involved in positive regulation of smooth muscle cell migration IDA
IDA: Inferred from direct assay
11368999 RGD
involved in response to X-ray IEP
IEP: Inferred from expression pattern
4170424 RGD
involved in response to cycloheximide IEP
IEP: Inferred from expression pattern
444225 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
20838740 RGD
involved in response to genistein IEP
IEP: Inferred from expression pattern
20838740 RGD
involved in response to growth hormone IEP
IEP: Inferred from expression pattern
4211972 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
4211972 RGD
involved in response to thyroid hormone IEP
IEP: Inferred from expression pattern
4211972 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
6169715 RGD
Cellular Component GO Annotation Evidence References Source
located in blood microparticle IDA
IDA: Inferred from direct assay
22014850 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
24667622 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fibrinogen alpha chain

  • fibrinogen, A alpha polypeptide

  • fibrinogen, alpha polypeptide

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-161244 FGA145 Inhibitor / Unkown
HY-161245 FGA146 Inhibitor / Unkown
HY-172977 FGA139 Inhibitor / Unkown
HY-RS04878 FGA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17677 Fga Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24138 Fga Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fga NCBI NCBI:2243